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    Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314785, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tmtc3provided by RGD
    Official Full Name
    transmembrane O-mannosyltransferase targeting cadherins 3provided by RGD
    Primary source
    RGD:1306351
    See related
    EnsemblRapid:ENSRNOG00000006749 AllianceGenome:RGD:1306351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306351
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in positive regulation of proteasomal protein catabolic process; protein O-linked mannosylation; and response to endoplasmic reticulum stress. Predicted to act upstream of or within several processes, including lung development; muscle cell development; and post-embryonic development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in lissencephaly 8. Orthologous to human TMTC3 (transmembrane O-mannosyltransferase targeting cadherins 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 112.9), Heart (RPKM 91.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmtc3 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (37151456..37196550, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (35264886..35310010, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (40171957..40217056, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene centrosomal protein 290 Neighboring gene transfer RNA proline (anticodon GGG) 7 Neighboring gene RNA 5'-phosphate and 3'-OH ligase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. Racapé M, et al. PLoS One, 2011. PMID 21603654, Free PMC Article
    2. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Larsen ISB, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973932, Free PMC Article
    3. mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. Yun EJ, et al. Anat Rec (Hoboken), 2012 Jan. PMID 21956870
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bud outgrowth involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein O-mannosyl-transferase TMTC3
    Names
    transmembrane and TPR repeat-containing protein 3
    transmembrane and tetratricopeptide repeat containing 3
    NP_001129330.1
    XP_038935012.1
    XP_063119535.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135858.2 → NP_001129330.1  protein O-mannosyl-transferase TMTC3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IG92, D3ZUJ8
      Related
      ENSRNOP00000037617.6, ENSRNOT00000029045.6
      Conserved Domains (5) summary
      COG0457
      Location:400 → 688
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:535 → 562
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:602 → 635
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:263 → 336
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:672 → 738
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      37151456..37196550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079084.2 → XP_038935012.1  protein O-mannosyl-transferase TMTC3 isoform X1

      Conserved Domains (4) summary
      TIGR02917
      Location:204 → 571
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:299 → 326
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:28 → 100
      DUF1736; Domain of unknown function (DUF1736)
      cl28891
      Location:563 → 605
      ParB_N_Srx; ParB N-terminal domain and sulfiredoxin protein-related families

    2. XM_063263465.1 → XP_063119535.1  protein O-mannosyl-transferase TMTC3 isoform X2

    RNA

    1. XR_010052970.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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