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    Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25262, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itpr1provided by RGD
    Official Full Name
    inositol 1,4,5-trisphosphate receptor, type 1provided by RGD
    Primary source
    RGD:2933
    See related
    EnsemblRapid:ENSRNOG00000007104 AllianceGenome:RGD:2933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P400; IP3R1; I145TR; InsP3R; InsP3R1
    Summary
    This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 805.4), Kidney (RPKM 503.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Itpr1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (142743401..143066505)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (141187377..141554240)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (140247297..140580749)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SET domain and mariner transposase fusion gene Neighboring gene uncharacterized LOC134486831 Neighboring gene sulfatase modifying factor 1 Neighboring gene uncharacterized LOC102547466 Neighboring gene uncharacterized LOC108350742 Neighboring gene basic helix-loop-helix family, member e40

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables calcium channel inhibitor activity  
    enables calcium channel inhibitor activity  
    enables calcium ion binding  
    enables identical protein binding PubMed 
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels  
    enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables intracellularly gated calcium channel activity  
    enables intracellularly gated calcium channel activity  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein phosphatase binding PubMed 
    enables protein-containing complex binding PubMed 
    enables transmembrane transporter binding PubMed 
    Items 1 - 25 of 30
    Items 1 - 25 of 58
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion PubMed 
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in cell morphogenesis  
    involved_in cell morphogenesis  
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in dendrite development PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis  
    acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis  
    involved_in epithelial fluid transport  
    involved_in epithelial fluid transport  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
    involved_in ligand-gated ion channel signaling pathway  
    involved_in ligand-gated ion channel signaling pathway  
    involved_in liver regeneration PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of calcium-mediated signaling  
    involved_in negative regulation of calcium-mediated signaling  
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of calcium ion transport PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of hepatocyte proliferation PubMed 
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in protein homotetramerization PubMed 
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol PubMed 
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum  
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum  
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in single fertilization  
    involved_in single fertilization  
    involved_in single fertilization  
    involved_in voluntary musculoskeletal movement  
    acts_upstream_of_or_within voluntary musculoskeletal movement  
    Items 1 - 25 of 58
    Items 1 - 20 of 42
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    part_of calcineurin complex  
    part_of calcineurin complex  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in membrane PubMed 
    located_in neuronal cell body PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear inner membrane  
    located_in nuclear inner membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in platelet dense granule membrane  
    located_in platelet dense granule membrane  
    located_in platelet dense tubular network  
    located_in platelet dense tubular network  
    is_active_in postsynapse PubMed 
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in presynapse PubMed 
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    is_active_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum  
    is_active_in secretory granule membrane  
    is_active_in smooth endoplasmic reticulum membrane PubMed 
    is_active_in synapse  
    located_in synaptic membrane PubMed 
    located_in transport vesicle membrane  
    Items 1 - 20 of 42

    General protein information

    Preferred Names
    inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; inositol 1,4,5-trisphosphate receptor type 1
    Names
    IP-3-R
    IP3 receptor
    IP3R 1
    inositol 1,4,5-triphosphate receptor 1
    inositol 1,4,5-triphosphate receptor, type 1
    type 1 InsP3 receptor
    type 1 inositol 1,4,5-trisphosphate receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007235.2NP_001007236.2  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 1

      See identical proteins and their annotated locations for NP_001007236.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC091346, BF402715, GQ233032, J05510
      UniProtKB/Swiss-Prot
      P29994, Q62869
      UniProtKB/TrEMBL
      C7E1V2, F1LQS8
      Conserved Domains (6) summary
      smart00472
      Location:231287
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam00520
      Location:23402599
      Ion_trans; Ion transport protein
      pfam01365
      Location:476665
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19632068
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    2. NM_001270596.1NP_001257525.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC091346, BF402715, GQ233032, J05510
      UniProtKB/Swiss-Prot
      P29994, Q62869
      Related
      ENSRNOP00000111175.1, ENSRNOT00000151720.1
      Conserved Domains (6) summary
      smart00472
      Location:231287
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam00520
      Location:23252584
      Ion_trans; Ion transport protein
      pfam01365
      Location:461650
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19482053
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    3. NM_001270597.1NP_001257526.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC091346, BF402715, GQ233032, J05510, U38653
      UniProtKB/TrEMBL
      A0A0A0MY31
      Related
      ENSRNOP00000048661.5, ENSRNOT00000043646.6
      Conserved Domains (6) summary
      smart00472
      Location:231287
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam00520
      Location:23012560
      Ion_trans; Ion transport protein
      pfam01365
      Location:476665
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19242029
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      142743401..143066505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285577.1XP_063141647.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XAG4
      Related
      ENSRNOP00000063885.4, ENSRNOT00000064025.5
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