Creld1 cysteine-rich with EGF-like domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Creld1provided by RGD
Official Full Name: cysteine-rich with EGF-like domains 1provided by RGD
Primary source: RGD:1309412
See related: EnsemblRapid:ENSRNOG00000009414 AllianceGenome:RGD:1309412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 133.6), Brain (RPKM 126.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148187510..148197120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146631883..146641493)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145440284..145449894)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein disulfide isomerase Creld1

Names: cysteine-rich with EGF-like domain protein 1

NP_001019954.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024783.1 → NP_001019954.1 protein disulfide isomerase Creld1 precursor

See identical proteins and their annotated locations for NP_001019954.1

Status: PROVISIONAL

Source sequence(s)

BC097951

UniProtKB/Swiss-Prot

Q4V7F2

UniProtKB/TrEMBL

A6IBS5

Related

ENSRNOP00000013052.4, ENSRNOT00000013052.8

Conserved Domains (4) summary

smart00179
Location:305 → 337

EGF_CA; Calcium-binding EGF-like domain

smart00261
Location:210 → 245

FU; Furin-like repeats

pfam11938
Location:46 → 100

DUF3456; TLR4 regulator and MIR-interacting MSAP

cl21504
Location:245 → 272

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...