Ccnb2 cyclin B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccnb2provided by RGD
Official Full Name: cyclin B2provided by RGD
Primary source: RGD:1308176
See related: EnsemblRapid:ENSRNOG00000063216 AllianceGenome:RGD:1308176
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase binding activity. Predicted to be involved in negative regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within several processes, including T cell homeostasis; meiosis I cell cycle process; and thymus development. Predicted to be located in centrosome; cytosol; and membrane. Orthologous to human CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 245.4), Spleen (RPKM 157.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (79968459..79981717, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71087594..71100794, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (76847972..76861165, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results advance the knowledge of cell cycle regulators effects in tubular restoration and/or degeneration, and the cyclin b2 and CDC2 molecules are suggested to be a marker for the proliferation of proximal tubular cells in kidney failure.
Title: Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134040 (e-PCR)
- UniSTS:217322

PMC22491P1 (e-PCR)
- UniSTS:272112

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G2/MI transition of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly involved in female meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009470.1 → NP_001009470.1 G2/mitotic-specific cyclin-B2

See identical proteins and their annotated locations for NP_001009470.1

Status: PROVISIONAL

Source sequence(s)

BC088212

UniProtKB/TrEMBL

A0A8I6AAH8, A0A8I6AKM6, Q5M857

Related

ENSRNOP00000090642.2, ENSRNOT00000100541.2

Conserved Domains (2) summary

cd20570
Location:264 → 382

CYCLIN_CCNB2_rpt2; second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins

cl40454
Location:127 → 259

CYCLIN_SF; Cyclin box fold superfamily