Kcnq4 potassium voltage-gated channel subfamily Q member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnq4provided by RGD
Official Full Name: potassium voltage-gated channel subfamily Q member 4provided by RGD
Primary source: RGD:61799
See related: EnsemblRapid:ENSRNOG00000060435 AllianceGenome:RGD:61799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables potassium channel activity. Involved in negative regulation of dopaminergic synaptic transmission and potassium ion transport. Predicted to be located in basal plasma membrane. Predicted to be part of monoatomic ion channel complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 35.4), Lung (RPKM 11.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139560366..139612212, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134275145..134326992, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139625783..139677300, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that midbrain Kcnq4 expression regulates alcohol-related behaviors and provide evidence that KV7.4 channels are a critical mediator of excessive alcohol drinking.
Title: Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.
Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered.
Title: Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
EPAC-dependent vasorelaxations occur in part via activation of Kv7 channels. This contributes to the isoproterenol-mediated relaxation in mesenteric, but not renal, arteries.
Title: Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.
is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone.
Title: K(V)7.4 channels participate in the control of rodent renal vascular resting tone.
In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP.
Title: Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
Title: Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
In 2 different rat and mouse models of hypertension, the functional impact of Kv7 channels was dramatically downregulated.
Title: Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Findings show that K(V)7/KCNQ channels were functionally expressed in primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions.
Title: K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells.
KCNQ4 potassium channel contributes to the regulation of myogenic control of cerebral artery diameter.
Title: Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers.
Title: Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Kcnq4 (e-PCR), detects polymorphism
- UniSTS:507411

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 4

Names: KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; voltage-gated potassium channel subunit Kv7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419575.1 → NP_001406504.1 potassium voltage-gated channel subfamily KQT member 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

A0A0G2K666, Q9JK96

Related

ENSRNOP00000073695.1, ENSRNOT00000087445.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

139560366..139612212 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111224.2 → XP_038967152.1 potassium voltage-gated channel subfamily KQT member 4 isoform X1

Conserved Domains (2) summary

pfam00520
Location:98 → 330

Ion_trans; Ion transport protein

pfam03520
Location:433 → 612

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_008764110.4 → XP_008762332.1 potassium voltage-gated channel subfamily KQT member 4 isoform X3

Conserved Domains (3) summary

pfam00520
Location:126 → 330

Ion_trans; Ion transport protein

pfam03520
Location:416 → 599

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:246 → 320

Ion_trans_2; Ion channel
XM_039111225.2 → XP_038967153.1 potassium voltage-gated channel subfamily KQT member 4 isoform X2

Related

ENSRNOP00000107130.1, ENSRNOT00000126081.1

Conserved Domains (2) summary

pfam00520
Location:98 → 330

Ion_trans; Ion transport protein

pfam03520
Location:429 → 608

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_008764111.4 → XP_008762333.1 potassium voltage-gated channel subfamily KQT member 4 isoform X4

See identical proteins and their annotated locations for XP_008762333.1

UniProtKB/TrEMBL

A6IRZ1

Conserved Domains (3) summary

pfam00520
Location:2 → 192

Ion_trans; Ion transport protein

pfam03520
Location:332 → 515

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:108 → 182

Ion_trans_2; Ion channel
XM_039111226.2 → XP_038967154.1 potassium voltage-gated channel subfamily KQT member 4 isoform X5

Conserved Domains (1) summary

pfam00520
Location:98 → 330

Ion_trans; Ion transport protein