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    Atp2b4 ATPase plasma membrane Ca2+ transporting 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29600, updated on 9-Dec-2024

    Summary

    Symbol
    Atp2b4provided by RGD
    Full Name
    ATPase plasma membrane Ca2+ transporting 4provided by RGD
    Primary source
    RGD:621305
    See related
    EnsemblRapid:ENSRNOG00000003031 AllianceGenome:RGD:621305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PMCA4
    Summary
    Enables P-type calcium transporter activity; PDZ domain binding activity; and protein kinase binding activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Located in basolateral plasma membrane and sperm principal piece. Is active in glutamatergic synapse and presynaptic active zone membrane. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 146.2), Lung (RPKM 129.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Atp2b4 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47708157..47807389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45156137..45255292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50091644..50153808)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352533 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10, pseudogene 1 Neighboring gene uncharacterized LOC120096250 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene uncharacterized LOC134481499 Neighboring gene uncharacterized LOC134481498 Neighboring gene uncharacterized LOC102557118 Neighboring gene opticin Neighboring gene proline and arginine rich end leucine rich repeat protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity PubMed 
    enables P-type calcium transporter activity PubMed 
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables PDZ domain binding PubMed 
    enables calcium ion transmembrane transporter activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables metal ion binding  
    enables nitric-oxide synthase binding  
    enables nitric-oxide synthase inhibitor activity  
    enables protein kinase binding PubMed 
    enables protein phosphatase 2B binding  
    enables scaffold protein binding  
    enables sodium channel regulator activity  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in calcium ion export PubMed 
    involved_in calcium ion export  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport PubMed 
    involved_in cellular response to acetylcholine  
    involved_in cellular response to acetylcholine  
    involved_in cellular response to epinephrine stimulus  
    involved_in flagellated sperm motility  
    involved_in flagellated sperm motility  
    involved_in hippocampus development PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of arginine catabolic process  
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress  
    involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus  
    involved_in negative regulation of citrulline biosynthetic process  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in negative regulation of nitric-oxide synthase activity  
    involved_in negative regulation of the force of heart contraction  
    involved_in neural retina development PubMed 
    acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in regulation of cell cycle G1/S phase transition  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to hydrostatic pressure  
    involved_in spermatogenesis PubMed 
    involved_in urinary bladder smooth muscle contraction  
    involved_in urinary bladder smooth muscle contraction  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in Z disc  
    located_in basolateral plasma membrane PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynaptic active zone membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 
    part_of protein-containing complex  
    located_in sarcolemma  
    located_in sperm flagellum  
    located_in sperm principal piece PubMed 

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 4
    Names
    ATPase, Ca++ transporting, plasma membrane 4
    plasma membrane Ca2+-ATPases 4
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_001005871.1
    XP_008767668.1
    XP_038946568.1
    XP_038946569.1
    XP_038946570.1
    XP_038946571.1
    XP_038946572.1
    XP_038946574.1
    XP_063128279.1
    XP_063128280.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005871.1NP_001005871.1  plasma membrane calcium-transporting ATPase 4

      See identical proteins and their annotated locations for NP_001005871.1

      Status: PROVISIONAL

      Source sequence(s)
      U15408
      UniProtKB/TrEMBL
      A6IC90
      Related
      ENSRNOP00000004078.6, ENSRNOT00000004078.8
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891126
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      47708157..47807389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090642.2XP_038946570.1  plasma membrane calcium-transporting ATPase 4 isoform X2

      UniProtKB/TrEMBL
      A6IC89
      Related
      ENSRNOP00000080557.1, ENSRNOT00000112237.2
      Conserved Domains (2) summary
      TIGR01517
      Location:161040
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10771122
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. XM_039090644.2XP_038946572.1  plasma membrane calcium-transporting ATPase 4 isoform X4

      UniProtKB/TrEMBL
      A6IC90
      Conserved Domains (2) summary
      TIGR01517
      Location:161040
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10771114
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. XM_039090640.2XP_038946568.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Related
      ENSRNOP00000039880.5, ENSRNOT00000046273.6
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    4. XM_039090646.2XP_038946574.1  plasma membrane calcium-transporting ATPase 4 isoform X6

      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891172
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    5. XM_039090643.2XP_038946571.1  plasma membrane calcium-transporting ATPase 4 isoform X3

      UniProtKB/TrEMBL
      A6IC90
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891126
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    6. XM_008769446.4XP_008767668.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      See identical proteins and their annotated locations for XP_008767668.1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    7. XM_063272209.1XP_063128279.1  plasma membrane calcium-transporting ATPase 4 isoform X3

      UniProtKB/TrEMBL
      A6IC90
    8. XM_039090641.2XP_038946569.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    9. XM_063272210.1XP_063128280.1  plasma membrane calcium-transporting ATPase 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AQE5
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