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    Bdh2 3-hydroxybutyrate dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295458, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bdh2provided by RGD
    Official Full Name
    3-hydroxybutyrate dehydrogenase 2provided by RGD
    Primary source
    RGD:1309898
    See related
    EnsemblRapid:ENSRNOG00000014490 AllianceGenome:RGD:1309898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dhrs6
    Summary
    Predicted to enable 3-hydroxybutyrate dehydrogenase activity; NAD binding activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid beta-oxidation; heme metabolic process; and siderophore biosynthetic process. Predicted to act upstream of with a positive effect on intracellular sequestering of iron ion. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 285.2), Heart (RPKM 53.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Bdh2 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226376346..226397010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223702410..223723076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240461505..240482149)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 12A, pseudogene 1 Neighboring gene centromere protein E Neighboring gene solute carrier family 9 member B2 Neighboring gene solute carrier family 9 member B1 Neighboring gene uncharacterized LOC134485973

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation  
    involved_in epithelial cell differentiation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in heme metabolic process  
    acts_upstream_of_positive_effect intracellular sequestering of iron ion  
    acts_upstream_of_positive_effect intracellular sequestering of iron ion  
    involved_in siderophore biosynthetic process  
    involved_in siderophore biosynthetic process  
    involved_in siderophore biosynthetic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    NOT located_in mitochondrion  

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 6
    Names
    (R)-beta-hydroxybutyrate dehydrogenase
    3-hydroxybutyrate dehydrogenase, type 2
    4-oxo-L-proline reductase
    R-beta-hydroxybutyrate dehydrogenase
    dehydrogenase/reductase (SDR family) member 6
    oxidoreductase UCPA
    short chain dehydrogenase/reductase family 15C member 1
    NP_001099943.1
    XP_006233384.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106473.1NP_001099943.1  dehydrogenase/reductase SDR family member 6

      See identical proteins and their annotated locations for NP_001099943.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A0A0MXX5
      Related
      ENSRNOP00000019507.4, ENSRNOT00000019507.7
      Conserved Domains (2) summary
      cd05368
      Location:15255
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:12254
      PRK06138; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      226376346..226397010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233322.5XP_006233384.1  dehydrogenase/reductase SDR family member 6 isoform X1

      See identical proteins and their annotated locations for XP_006233384.1

      UniProtKB/Swiss-Prot
      D4A1J4
      UniProtKB/TrEMBL
      A6HVW3
      Conserved Domains (2) summary
      cd05368
      Location:5245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2244
      PRK06138; short chain dehydrogenase; Provisional

    RNA

    1. XR_010063596.1 RNA Sequence

      Related
      ENSRNOT00000095079.2
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