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    Caprin2 caprin family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caprin2provided by RGD
    Official Full Name
    caprin family member 2provided by RGD
    Primary source
    RGD:1593683
    See related
    EnsemblRapid:ENSRNOG00000047319 AllianceGenome:RGD:1593683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adir; Rng140
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of dendritic spine morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including centrosome; mitochondrion; and nucleoplasm. Predicted to be part of receptor complex. Orthologous to human CAPRIN2 (caprin family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 34.3), Kidney (RPKM 33.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Caprin2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183537935..183592162, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181806105..181860754, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183304993..183374195, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like, pseudogene 1 Neighboring gene importin 8 Neighboring gene RNA, U2 small nuclear 45 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene phosphatidylinositol transfer protein, beta, pseudogene 1 Neighboring gene SIN3-HDAC complex associated factor Neighboring gene uncharacterized LOC134486897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions. Loh SY, et al. eNeuro, 2017 Nov-Dec. PMID 29279858, Free PMC Article
    2. RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response. Konopacka A, et al. Elife, 2015 Nov 12. PMID 26559902, Free PMC Article
    3. Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2. Bárez-López S, et al. Neuroendocrinology, 2022. PMID 35051932
    4. Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. Aerbajinai W, et al. J Biol Chem, 2004 Jan 16. PMID 14593112
    5. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. Shiina N, et al. J Biol Chem, 2010 Jul 30. PMID 20516077, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.
      Title: Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.
    2. Using the unsupervised graphical lasso (Glasso) algorithm, study reconstructed a putative network from 500 plastic supraoptic nucleus genes in which genes are the nodes and the edges are the inferred interactions. The most active nodal gene identified within the network was Caprin2. Overexpressio or knock down Caprin2 transcripts in PC12 cells had significant opposite effects on the levels of putative target mRNAs.
      Title: Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions.
    3. Caprin-2 knockdown in the hypothalamus decreases urine output and fluid intake, and increases urine osmolality, urine sodium concentration, and plasma arginine vasopressin levels.
      Title: RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response.
    4. RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules
      Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    caprin-2
    Names
    adiponectin r
    cytoplasmic activation/proliferation-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401070.1 → NP_001387999.1  caprin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0S1LIA8, M0R6B1
      Related
      ENSRNOP00000109644.1, ENSRNOT00000159367.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      183537935..183592162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286704.1 → XP_063142774.1  caprin-2 isoform X7

      UniProtKB/TrEMBL
      A0A0S1LIA8, M0R7N7
      Related
      ENSRNOP00000065469.3, ENSRNOT00000070907.4

    2. XM_063286701.1 → XP_063142771.1  caprin-2 isoform X3

      UniProtKB/TrEMBL
      A0A0S1LIA8, A0A8I6A0V8
      Related
      ENSRNOP00000084248.1, ENSRNOT00000097069.2

    3. XM_063286703.1 → XP_063142773.1  caprin-2 isoform X5

      UniProtKB/TrEMBL
      A0A0S1LIA8

    4. XM_063286702.1 → XP_063142772.1  caprin-2 isoform X9

      UniProtKB/TrEMBL
      A0A0S1LIA8

    5. XM_063286700.1 → XP_063142770.1  caprin-2 isoform X8

      UniProtKB/TrEMBL
      A0A0S1LIA8

    6. XM_039108911.2 → XP_038964839.1  caprin-2 isoform X5

      UniProtKB/TrEMBL
      A0A0S1LIA8
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:839 → 964
      C1q; C1q domain
      pfam12287
      Location:528 → 775
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    7. XM_063286705.1 → XP_063142775.1  caprin-2 isoform X7

      UniProtKB/TrEMBL
      A0A0S1LIA8, M0R7N7

    8. XM_039108910.2 → XP_038964838.1  caprin-2 isoform X4

      UniProtKB/TrEMBL
      A0A0S1LIA8, M0R6B1
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:901 → 1026
      C1q; C1q domain
      pfam12287
      Location:528 → 837
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    9. XM_063286699.1 → XP_063142769.1  caprin-2 isoform X6

      UniProtKB/TrEMBL
      A0A0S1LIA8
      Related
      ENSRNOP00000064956.4, ENSRNOT00000073927.5

    10. XM_039108913.2 → XP_038964841.1  caprin-2 isoform X7

      UniProtKB/TrEMBL
      A0A0S1LIA8, M0R7N7
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:822 → 947
      C1q; C1q domain
      pfam12287
      Location:528 → 758
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    11. XM_039108908.2 → XP_038964836.1  caprin-2 isoform X3

      UniProtKB/TrEMBL
      A0A0S1LIA8, A0A8I6A0V8
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:867 → 992
      C1q; C1q domain
      pfam12287
      Location:528 → 803
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    12. XM_039108906.2 → XP_038964834.1  caprin-2 isoform X2

      UniProtKB/TrEMBL
      A0A0S1LIA8
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:899 → 1024
      C1q; C1q domain
      pfam12287
      Location:528 → 835
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    13. XM_039108905.2 → XP_038964833.1  caprin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0S1LIA8
      Related
      ENSRNOP00000099753.1, ENSRNOT00000130293.1
      Conserved Domains (4) summary
      PRK03918
      Location:48 → 366
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00386
      Location:900 → 1025
      C1q; C1q domain
      pfam12287
      Location:528 → 837
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    14. XM_063286706.1 → XP_063142776.1  caprin-2 isoform X10

      UniProtKB/TrEMBL
      A0A0S1LIA8

    15. XM_039108918.2 → XP_038964846.1  caprin-2 isoform X12

      Conserved Domains (3) summary
      pfam17380
      Location:3 → 152
      DUF5401; Family of unknown function (DUF5401)
      pfam00386
      Location:653 → 778
      C1q; C1q domain
      pfam12287
      Location:280 → 589
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    16. XM_039108917.2 → XP_038964845.1  caprin-2 isoform X12

      Conserved Domains (3) summary
      pfam17380
      Location:3 → 152
      DUF5401; Family of unknown function (DUF5401)
      pfam00386
      Location:653 → 778
      C1q; C1q domain
      pfam12287
      Location:280 → 589
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    17. XM_039108916.2 → XP_038964844.1  caprin-2 isoform X11

      UniProtKB/TrEMBL
      A0A0S1LIA8
      Conserved Domains (4) summary
      pfam17380
      Location:54 → 207
      DUF5401; Family of unknown function (DUF5401)
      pfam00386
      Location:708 → 833
      C1q; C1q domain
      pfam12287
      Location:335 → 644
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:1 → 41
      Caprin-1_dimer; Caprin-1 dimerization domain

    18. XM_063286707.1 → XP_063142777.1  caprin-2 isoform X13

      UniProtKB/TrEMBL
      A6IN64
    Nucleotide Protein Strain
    Heading Accession and Version

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