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    Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galnt11provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 11provided by RGD
    Primary source
    RGD:735097
    See related
    EnsemblRapid:ENSRNOG00000008117 AllianceGenome:RGD:735097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in several processes, including Notch signaling involved in heart development; protein O-linked glycosylation via threonine; and regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 770.7), Liver (RPKM 164.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galnt11 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (10571464..10604974, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (9837629..9871141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6297255..6330765, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486540 Neighboring gene lysine methyltransferase 2C Neighboring gene microtubule-associated protein 1 light chain 3 beta, pseudogene 2 Neighboring gene ribosomal protein L30, pseudogene 8 Neighboring gene polypeptide N-acetylgalactosaminyltransferase-like 5 Neighboring gene calcineurin B homologous protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. Boskovski MT, et al. Nature, 2013 Dec 19. PMID 24226769, Free PMC Article
    2. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Notch binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch receptor processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Notch signaling involved in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in determination of left/right symmetry ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 11
    Names
    :polypeptide N-acetylgalactosaminyltransferase 11
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
    galNAc-T11
    polypeptide GalNAc transferase 11
    pp-GaNTase 11
    protein-UDP acetylgalactosaminyltransferase 11
    NP_001258248.1
    NP_955425.2
    XP_006235985.1
    XP_063142010.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271319.1 → NP_001258248.1  polypeptide N-acetylgalactosaminyltransferase 11

      See identical proteins and their annotated locations for NP_001258248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6P6V1
      UniProtKB/TrEMBL
      A0A0H2UHG8, A6KJI6
      Related
      ENSRNOP00000011815.4, ENSRNOT00000011814.9
      Conserved Domains (4) summary
      cd02510
      Location:155 → 453
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:488 → 607
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:484 → 605
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:155 → 383
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    2. NM_199393.2 → NP_955425.2  polypeptide N-acetylgalactosaminyltransferase 11

      See identical proteins and their annotated locations for NP_955425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC062004, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6P6V1
      UniProtKB/TrEMBL
      A0A0H2UHG8, A6KJI6
      Conserved Domains (4) summary
      cd02510
      Location:155 → 453
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:488 → 607
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:484 → 605
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:155 → 383
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      10571464..10604974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235923.5 → XP_006235985.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

      See identical proteins and their annotated locations for XP_006235985.1

      UniProtKB/Swiss-Prot
      Q6P6V1
      UniProtKB/TrEMBL
      A0A0H2UHG8, A6KJI6
      Conserved Domains (4) summary
      cd02510
      Location:155 → 453
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:488 → 607
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:484 → 605
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:155 → 383
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    2. XM_063285940.1 → XP_063142010.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X2

      UniProtKB/TrEMBL
      A6KJI5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6V1.1 GenPept UniProtKB/Swiss-Prot:Q6P6V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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