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    Mlf1 myeloid leukemia factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mlf1provided by RGD
    Official Full Name
    myeloid leukemia factor 1provided by RGD
    Primary source
    RGD:1306854
    See related
    EnsemblRapid:ENSRNOG00000012827 AllianceGenome:RGD:1306854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and protein domain specific binding activity. Predicted to be involved in DNA-templated transcription; myeloid progenitor cell differentiation; and regulation of DNA-templated transcription. Predicted to act upstream of with a positive effect on regulation of signal transduction by p53 class mediator. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Predicted to be located in several cellular components, including ciliary basal body; non-motile cilium; and perinuclear region of cytoplasm. Predicted to be active in ciliary base; cytoplasm; and nucleus. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2329.5), Testes (RPKM 766.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mlf1 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (153958060..153991705)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (151648492..151681654)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (164549423..164582645)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene arginine and serine rich coiled-coil 1 Neighboring gene uncharacterized LOC134485626 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene retinoic acid receptor responder 1 Neighboring gene latexin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Rangrez AY, et al. Biochim Biophys Acta Mol Cell Res, 2017 Apr. PMID 28087342
    2. HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1. Williams JH, et al. EMBO J, 1999 Oct 15. PMID 10523300, Free PMC Article
    3. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. Yoneda-Kato N, et al. EMBO J, 2005 May 4. PMID 15861129, Free PMC Article
    4. NPM mutations in acute myelogenous leukemia. Grisendi S, et al. N Engl J Med, 2005 Jan 20. PMID 15659732
    5. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. Winteringham LN, et al. J Biol Chem, 2006 Dec 15. PMID 17008314

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MLF1 is a novel modulator of neonatal rat cardiomyocytes proliferation.
      Title: Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in myeloid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid leukemia factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107680.1 → NP_001101150.1  myeloid leukemia factor 1

      See identical proteins and their annotated locations for NP_001101150.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A0A8I6ARE8, A6J5L2, D3ZCQ9
      Related
      ENSRNOP00000017151.4, ENSRNOT00000017151.9
      Conserved Domains (1) summary
      pfam10248
      Location:27 → 217
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      153958060..153991705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232477.5 → XP_006232539.1  myeloid leukemia factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006232539.1

      UniProtKB/TrEMBL
      A0A8I6AES2, A0A8I6ARE8, A6J5L3
      Related
      ENSRNOP00000094367.2, ENSRNOT00000109696.2
      Conserved Domains (1) summary
      pfam10248
      Location:27 → 202
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    2. XM_006232479.5 → XP_006232541.1  myeloid leukemia factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ARE8
      Conserved Domains (1) summary
      pfam10248
      Location:27 → 174
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    3. XM_063281801.1 → XP_063137871.1  myeloid leukemia factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARE8
    Nucleotide Protein Strain
    Heading Accession and Version

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