Malsu1 mitochondrial assembly of ribosomal large subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Malsu1provided by RGD
Official Full Name: mitochondrial assembly of ribosomal large subunit 1provided by RGD
Primary source: RGD:1306936
See related: AllianceGenome:RGD:1306936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306936
Summary: Predicted to enable mitochondrial large ribosomal subunit binding activity. Predicted to be involved in negative regulation of mitochondrial translation; negative regulation of ribosome biogenesis; and ribosomal large subunit biogenesis. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 145.5), Heart (RPKM 142.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (79381963..79390786)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (78051090..78059913)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (78735279..78744102)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitochondrial large ribosomal subunit binding	ISO Inferred from Sequence Orthology more info
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ribosome biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial assembly of ribosomal large subunit protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106593.1 → NP_001100063.1 mitochondrial assembly of ribosomal large subunit protein 1

See identical proteins and their annotated locations for NP_001100063.1

Status: PROVISIONAL

Source sequence(s)

CH474011

UniProtKB/TrEMBL

A6K0K3, D3ZZ37

Conserved Domains (1) summary

pfam02410
Location:90 → 189

RsfS; Ribosomal silencing factor during starvation