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    Eps8l1 EPS8-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eps8l1provided by RGD
    Official Full Name
    EPS8-like 1provided by RGD
    Primary source
    RGD:1311146
    See related
    EnsemblRapid:ENSRNOG00000027942 AllianceGenome:RGD:1311146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable T cell receptor binding activity and actin binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in ruffle membrane. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 114.4), Kidney (RPKM 23.7) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eps8l1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78386916..78409972, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69343202..69359778, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72926106..72942433, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin T1, slow skeletal type Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene retinol dehydrogenase 13 Neighboring gene glycoprotein VI

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. Kesti T, et al. J Immunol, 2007 Jul 15. PMID 17617578
    2. MALS is a binding partner of IRSp53 at cell-cell contacts. Hori K, et al. FEBS Lett, 2003 Nov 6. PMID 14596909
    3. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Offenhäuser N, et al. Mol Biol Cell, 2004 Jan. PMID 14565974, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108467.1 → NP_001101937.1  epidermal growth factor receptor kinase substrate 8-like protein 1

      See identical proteins and their annotated locations for NP_001101937.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474075
      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Related
      ENSRNOP00000095614.1, ENSRNOT00000105965.2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78386916..78409972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081494.2 → XP_038937422.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. XM_006228280.4 → XP_006228342.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228342.1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. XM_006228278.4 → XP_006228340.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228340.1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_008758941.3 → XP_008757163.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008757163.1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    5. XM_006228279.4 → XP_006228341.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228341.1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    6. XM_006228282.4 → XP_006228344.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228344.1

      UniProtKB/TrEMBL
      A6KNL4, D3ZDV2
      Conserved Domains (4) summary
      cd09540
      Location:623 → 688
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:482 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      COG5373
      Location:159 → 244
      COG5373; Uncharacterized membrane protein [Function unknown]
      cd01210
      Location:32 → 162
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    7. XM_063266295.1 → XP_063122365.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZDV2

    RNA

    1. XR_350145.5 RNA Sequence

    2. XR_005487826.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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