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    Elapor2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elapor2provided by RGD
    Official Full Name
    endosome-lysosome associated apoptosis and autophagy regulator family member 2provided by RGD
    Primary source
    RGD:1563349
    See related
    EnsemblRapid:ENSRNOG00000005818 AllianceGenome:RGD:1563349
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563349
    Summary
    Predicted to be involved in positive regulation of BMP signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human ELAPOR2 (endosome-lysosome associated apoptosis and autophagy regulator family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 149.0), Lung (RPKM 25.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elapor2 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (25565298..25760684, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (24613163..24805729, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (21563848..21757668, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6, pseudogene 11 Neighboring gene translocase of inner mitochondrial membrane 8 homolog A-like Neighboring gene glutamate metabotropic receptor 3 Neighboring gene uncharacterized LOC108350658 Neighboring gene microRNA 879 Neighboring gene uncharacterized LOC102555663 Neighboring gene cyclin D binding myb-like transcription factor 1 Neighboring gene transmembrane protein 243

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development. Araki T, et al. J Biol Chem, 2011 Feb 25. PMID 21177533, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endosome/lysosome-associated apoptosis and autophagy regulator family member 2
    Names
    UPF0577 protein KIAA1324-like homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109345.1 → NP_001102815.1  endosome/lysosome-associated apoptosis and autophagy regulator family member 2

      See identical proteins and their annotated locations for NP_001102815.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474013
      UniProtKB/TrEMBL
      A0A8I6AGD6, A6K224, F1M4B6
      Related
      ENSRNOP00000092864.1, ENSRNOT00000100645.2
      Conserved Domains (1) summary
      pfam07699
      Location:401 → 431
      GCC2_GCC3; GCC2 and GCC3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      25565298..25760684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108238.2 → XP_038964166.1  endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X2

      UniProtKB/TrEMBL
      F1M4B6
      Conserved Domains (1) summary
      pfam07699
      Location:288 → 318
      Ephrin_rec_like; Putative ephrin-receptor like

    2. XM_063286607.1 → XP_063142677.1  endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X1

      UniProtKB/TrEMBL
      F1M4B6
      Related
      ENSRNOP00000100005.1, ENSRNOT00000145109.1

    3. XM_063286608.1 → XP_063142678.1  endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X3

    RNA

    1. XR_010065695.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials