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    Krt71 keratin 71 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683613, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt71provided by RGD
    Official Full Name
    keratin 71provided by RGD
    Primary source
    RGD:1584538
    See related
    EnsemblRapid:ENSRNOG00000049495 AllianceGenome:RGD:1584538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair follicle morphogenesis; intermediate filament organization; and keratinization. Predicted to be active in keratin filament. Used to study alopecia. Human ortholog(s) of this gene implicated in hypotrichosis 13. Orthologous to human KRT71 (keratin 71). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 47.9), Brain (RPKM 10.7) and 3 other tissues See more
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    Genomic context

    See Krt71 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134752240..134778765, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132873532..132898975, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143345201..143371346, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 6A Neighboring gene keratin 5 Neighboring gene keratin 72 Neighboring gene keratin 73

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in hair follicle morphogenesis  
    involved_in intermediate filament organization  
    involved_in intermediate filament organization  
    involved_in keratinization  
    Component Evidence Code Pubs
    is_active_in keratin filament  
    located_in keratin filament  

    General protein information

    Preferred Names
    keratin 71
    Names
    keratin 71, type II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276440.1 → NP_001263369.1  keratin 71

      See identical proteins and their annotated locations for NP_001263369.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCR3, U3R784, U3R7A7, U5LJQ0
      Related
      ENSRNOP00000059953.3, ENSRNOT00000068533.5
      Conserved Domains (2) summary
      pfam00038
      Location:130 → 443
      Filament; Intermediate filament protein
      pfam16208
      Location:15 → 127
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134752240..134778765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079885.2 → XP_038935813.1  keratin 71 isoform X1

      UniProtKB/TrEMBL
      A6KCR3, U3R784, U3R7A7, U5LJQ0
      Conserved Domains (2) summary
      pfam00038
      Location:130 → 443
      Filament; Intermediate filament protein
      pfam16208
      Location:15 → 127
      Keratin_2_head; Keratin type II head
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