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    Bnip3 BCL2 interacting protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84480, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bnip3provided by RGD
    Official Full Name
    BCL2 interacting protein 3provided by RGD
    Primary source
    RGD:620800
    See related
    EnsemblRapid:ENSRNOG00000017243 AllianceGenome:RGD:620800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Involved in several processes, including autophagic cell death; cardiac muscle cell apoptotic process; and central nervous system development. Located in cytoplasm; dendrite; and nucleoplasm. Used to study congestive heart failure. Biomarker of several diseases, including cerebrovascular disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; obesity; and retinal detachment. Orthologous to human BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1665.1), Heart (RPKM 1061.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Bnip3 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203137778..203154962, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (193708164..193725348, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211248098..211265282, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 Neighboring gene protein phosphatase 2, regulatory subunit B, delta Neighboring gene uncharacterized LOC102553541 Neighboring gene janus kinase and microtubule interacting protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC93043

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding  
    enables endoplasmic reticulum-autophagosome adaptor activity  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables mitochondrion autophagosome adaptor activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 52
    Process Evidence Code Pubs
    involved_in autophagic cell death PubMed 
    acts_upstream_of_or_within brown fat cell differentiation  
    involved_in cardiac muscle cell apoptotic process PubMed 
    involved_in cellular response to cobalt ion  
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hypoxia PubMed 
    acts_upstream_of_or_within cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    involved_in cellular response to mechanical stimulus  
    involved_in cerebral cortex development PubMed 
    involved_in defense response to virus  
    involved_in defense response to virus  
    involved_in granzyme-mediated programmed cell death signaling pathway  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia  
    involved_in mitochondrial fragmentation involved in apoptotic process  
    involved_in mitochondrial outer membrane permeabilization  
    involved_in mitochondrial outer membrane permeabilization  
    involved_in mitochondrial protein catabolic process  
    involved_in mitophagy  
    involved_in negative regulation of membrane potential  
    involved_in negative regulation of membrane potential  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process PubMed 
    involved_in negative regulation of mitochondrial membrane potential PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death  
    involved_in neuron apoptotic process PubMed 
    involved_in oligodendrocyte differentiation PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of autophagy of mitochondrion PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of macroautophagy  
    involved_in positive regulation of mitochondrial calcium ion concentration PubMed 
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of protein-containing complex disassembly  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    involved_in reactive oxygen species metabolic process  
    involved_in reactive oxygen species metabolic process  
    involved_in regulation of mitochondrial membrane permeability  
    involved_in regulation of mitochondrial membrane permeability  
    involved_in response to axon injury PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to hyperoxia PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to oxygen-glucose deprivation PubMed 
    involved_in reticulophagy  
    Items 1 - 25 of 52
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    is_active_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in mitochondrial membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrial outer membrane  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    is_active_in nuclear envelope  
    located_in nuclear envelope  
    located_in nuclear envelope  
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in postsynaptic density  

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
    Names
    BCL2/adenovirus E1B 19 kDa-interacting protein 3
    BCL2/adenovirus E1B interacting protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053420.3NP_445872.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

      See identical proteins and their annotated locations for NP_445872.1

      Status: VALIDATED

      Source sequence(s)
      BC070958, CO403082
      UniProtKB/TrEMBL
      A6HX99, A6INV7, F7FHM5, Q9ET45
      Related
      ENSRNOP00000023477.4, ENSRNOT00000023477.8
      Conserved Domains (1) summary
      pfam06553
      Location:2185
      BNIP3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203137778..203154962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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