Srek1 splicing regulatory glutamic acid and lysine rich protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srek1provided by RGD
Official Full Name: splicing regulatory glutamic acid and lysine rich protein 1provided by RGD
Primary source: RGD:621696
See related: EnsemblRapid:ENSRNOG00000032735 AllianceGenome:RGD:621696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sfrs12; Srrp86; Srsf12
Summary: Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 166.6), Thymus (RPKM 153.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (36583412..36618978, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (34849548..34885120, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (33806035..33841594, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: splicing regulatory glutamine/lysine-rich protein 1

Names: SR-related protein of 86 kDa; serine/arginine-rich splicing factor 12; serine/arginine-rich-splicing regulatory protein 86; splicing factor, arginine/serine-rich 12; splicing regulatory glutamic acid/lysine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412515.1 → NP_001399444.1 splicing regulatory glutamine/lysine-rich protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6A4G5, A0A8I6AGJ5, A6I5E3

Related

ENSRNOP00000093834.1, ENSRNOT00000098044.2
NM_020092.2 → NP_064477.2 splicing regulatory glutamine/lysine-rich protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9JKL7

UniProtKB/TrEMBL

A6I5E4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

36583412..36618978 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102993.2 → XP_038958921.1 splicing regulatory glutamine/lysine-rich protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AGJ5

Related

ENSRNOP00000085824.2, ENSRNOT00000102302.2

Conserved Domains (2) summary

cd12260
Location:178 → 263

RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

cd12519
Location:20 → 99

RRM1_SREK1; RNA recognition motif 1 (RRM1) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
XM_063282421.1 → XP_063138491.1 splicing regulatory glutamine/lysine-rich protein 1 isoform X2

UniProtKB/Swiss-Prot

Q9JKL7

UniProtKB/TrEMBL

A6I5E4
XM_039102994.2 → XP_038958922.1 splicing regulatory glutamine/lysine-rich protein 1 isoform X3

UniProtKB/Swiss-Prot

Q9JKL7

Conserved Domains (1) summary

cd12260
Location:62 → 147

RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
XM_063282422.1 → XP_063138492.1 splicing regulatory glutamine/lysine-rich protein 1 isoform X4