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    Ranbp3 RAN binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ranbp3provided by RGD
    Official Full Name
    RAN binding protein 3provided by RGD
    Primary source
    RGD:1589604
    See related
    EnsemblRapid:ENSRNOG00000049785 AllianceGenome:RGD:1589604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable R-SMAD binding activity and small GTPase binding activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in protein export from nucleus. Predicted to be located in nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Orthologous to human RANBP3 (RAN binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 141.7), Spleen (RPKM 125.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ranbp3 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1594344..1631587)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1507233..1544460)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10344190..10381415, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene calcyphosine Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human RanBP3, a group of nuclear RanGTP binding proteins. Mueller L, et al. FEBS Lett, 1998 May 15. PMID 9637251
    2. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dai F, et al. Dev Cell, 2009 Mar. PMID 19289081, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ran-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399356.1 → NP_001386285.1  ran-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZS95
      Related
      ENSRNOP00000097654.1, ENSRNOT00000110265.2
      Conserved Domains (1) summary
      cd13180
      Location:317 → 432
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1594344..1631587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244358.5 → XP_006244420.1  ran-binding protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006244420.1

      UniProtKB/TrEMBL
      A0A8I5ZVI9, A6KQV8, M0RD63
      Related
      ENSRNOP00000064728.4, ENSRNOT00000072911.5
      Conserved Domains (1) summary
      cd13180
      Location:384 → 499
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    2. XM_063267656.1 → XP_063123726.1  ran-binding protein 3 isoform X8

    3. XM_039084331.2 → XP_038940259.1  ran-binding protein 3 isoform X6

      Conserved Domains (1) summary
      cl17171
      Location:393 → 443
      PH-like; Pleckstrin homology-like domain

    4. XM_006244357.5 → XP_006244419.1  ran-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006244419.1

      UniProtKB/TrEMBL
      A0A8I5ZVI9
      Related
      ENSRNOP00000067560.4, ENSRNOT00000071228.5
      Conserved Domains (1) summary
      cd13180
      Location:393 → 508
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    5. XM_006244359.5 → XP_006244421.1  ran-binding protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006244421.1

      UniProtKB/TrEMBL
      A0A8I5ZVI9, M0R920
      Related
      ENSRNOP00000065980.3, ENSRNOT00000072009.4
      Conserved Domains (1) summary
      cd13180
      Location:331 → 446
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    6. XM_006244360.5 → XP_006244422.1  ran-binding protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006244422.1

      UniProtKB/TrEMBL
      A0A8I5ZS95, M0R5Q3
      Conserved Domains (1) summary
      cd13180
      Location:326 → 441
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    7. XM_006244362.5 → XP_006244424.1  ran-binding protein 3 isoform X7

      See identical proteins and their annotated locations for XP_006244424.1

      UniProtKB/TrEMBL
      A0A8I5ZS95, A6KQV7
      Conserved Domains (1) summary
      cd13180
      Location:264 → 379
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    8. XM_039084332.2 → XP_038940260.1  ran-binding protein 3 isoform X9

      UniProtKB/TrEMBL
      A6KQV9, A6KQW1
      Conserved Domains (1) summary
      cd13180
      Location:192 → 307
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    9. XM_039084330.2 → XP_038940258.1  ran-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      A6KQV9
      Conserved Domains (1) summary
      cd13180
      Location:278 → 393
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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