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    Bex1 brain expressed X-linked 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501625, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bex1provided by RGD
    Official Full Name
    brain expressed X-linked 1provided by RGD
    Primary source
    RGD:1564643
    See related
    EnsemblRapid:ENSRNOG00000033844 AllianceGenome:RGD:1564643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bex; Bex2; Bex1h
    Summary
    Predicted to enable molecular function inhibitor activity and signaling receptor binding activity. Acts upstream of or within negative regulation of neuron differentiation and positive regulation of neuroblast proliferation. Located in cytoplasm and nucleus. Orthologous to human BEX1 (brain expressed X-linked 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
    Expression
    Biased expression in Thymus (RPKM 183.5), Brain (RPKM 179.3) and 7 other tissues See more
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    Genomic context

    See Bex1 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (104010639..104012143, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (99219014..99220518, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A like 8 Neighboring gene transcription elongation factor A like 5 Neighboring gene uncharacterized LOC134484140 Neighboring gene transcription elongation factor A like 7 Neighboring gene programmed cell death 6, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables molecular function inhibitor activity  
    enables molecular function inhibitor activity  
    enables molecular function inhibitor activity  
    enables protein binding PubMed 
    enables signaling receptor binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    protein BEX1
    Names
    EG2RVC
    brain expressed X-linked 2
    brain expressed gene 1
    brain-expressed X-linked protein 1 homolog
    brain-expressed X-linked protein 2 homolog
    protein BEX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037365.2NP_001032442.1  protein BEX1

      See identical proteins and their annotated locations for NP_001032442.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q3MKQ2, Q6XUZ8
      UniProtKB/TrEMBL
      A0A096MIT8, A6KT21
      Related
      ENSRNOP00000039471.4, ENSRNOT00000048996.5
      Conserved Domains (1) summary
      pfam04538
      Location:13124
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      104010639..104012143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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