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    Mrpl1 mitochondrial ribosomal protein L1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289491, updated on 9-Dec-2024

    Summary

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    Symbol
    Mrpl1provided by RGD
    Full Name
    mitochondrial ribosomal protein L1provided by RGD
    Primary source
    RGD:1306850
    See related
    EnsemblRapid:ENSRNOG00000002070 AllianceGenome:RGD:1306850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of large ribosomal subunit. Orthologous to human MRPL1 (mitochondrial ribosomal protein L1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 83.7), Heart (RPKM 82.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (13604498..13663633, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (13300522..13359654, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14951507..15008136, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene uncharacterized LOC103693729 Neighboring gene uncharacterized LOC120096573 Neighboring gene U2 spliceosomal RNA Neighboring gene CCR4-NOT transcription complex, subunit 6-like Neighboring gene C-X-C motif chemokine ligand 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL1m
    Names
    39S ribosomal protein L1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105997.2 → NP_001099467.1  large ribosomal subunit protein uL1m

      See identical proteins and their annotated locations for NP_001099467.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168772
      UniProtKB/TrEMBL
      B5DER4, F1M9A4
      Related
      ENSRNOP00000002834.8, ENSRNOT00000002834.8
      Conserved Domains (1) summary
      TIGR01170
      Location:99 → 241
      rplA_mito; ribosomal protein uL1, mitochondrial

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      13604498..13663633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091672.2 → XP_038947600.1  large ribosomal subunit protein uL1m isoform X2

      Conserved Domains (1) summary
      cl00322
      Location:20 → 162
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    2. XM_039091670.2 → XP_038947598.1  large ribosomal subunit protein uL1m isoform X1

      UniProtKB/TrEMBL
      D3ZFE9, F1M9A4
      Related
      ENSRNOP00000070016.3, ENSRNOT00000085278.3
      Conserved Domains (1) summary
      TIGR01170
      Location:86 → 228
      rplA_mito; ribosomal protein uL1, mitochondrial

    3. XM_063272899.1 → XP_063128969.1  large ribosomal subunit protein uL1m isoform X3

    4. XM_039091673.2 → XP_038947601.1  large ribosomal subunit protein uL1m isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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