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    Cdc42ep1 CDC42 effector protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc42ep1provided by RGD
    Official Full Name
    CDC42 effector protein 1provided by RGD
    Primary source
    RGD:1311131
    See related
    EnsemblRapid:ENSRNOG00000008517 AllianceGenome:RGD:1311131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP1 (CDC42 effector protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 208.6), Heart (RPKM 125.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc42ep1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112275759..112283665)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110395287..110403203)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120063256..120071154)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene caspase recruitment domain family, member 10 Neighboring gene galectin 2 Neighboring gene uncharacterized LOC134479608 Neighboring gene uncharacterized LOC120093687 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
    2. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
    3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cdc42 effector protein 1
    Names
    CDC42 effector protein (Rho GTPase binding) 1
    binder of Rho GTPases 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079700.1 → NP_001073168.1  cdc42 effector protein 1

      See identical proteins and their annotated locations for NP_001073168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128744
      UniProtKB/Swiss-Prot
      A1A5P0
      UniProtKB/TrEMBL
      A0A8I5ZKG9
      Conserved Domains (2) summary
      pfam14957
      Location:117 → 232
      BORG_CEP; Cdc42 effector
      cl00113
      Location:37 → 64
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112275759..112283665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594868.2 → XP_017450357.1  cdc42 effector protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A1A5P0
      UniProtKB/TrEMBL
      A0A8I5ZKG9
      Related
      ENSRNOP00000078201.2, ENSRNOT00000101077.2
      Conserved Domains (2) summary
      pfam14957
      Location:117 → 232
      BORG_CEP; Cdc42 effector
      cl00113
      Location:37 → 64
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_017594865.3 → XP_017450354.1  cdc42 effector protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A1A5P0
      UniProtKB/TrEMBL
      A0A8I5ZKG9
      Conserved Domains (2) summary
      pfam14957
      Location:117 → 232
      BORG_CEP; Cdc42 effector
      cl00113
      Location:37 → 64
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_017594867.3 → XP_017450356.1  cdc42 effector protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A1A5P0
      UniProtKB/TrEMBL
      A0A8I5ZKG9
      Conserved Domains (2) summary
      pfam14957
      Location:117 → 232
      BORG_CEP; Cdc42 effector
      cl00113
      Location:37 → 64
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5P0.1 GenPept UniProtKB/Swiss-Prot:A1A5P0

    Gene LinkOut

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