U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Bmp7 bone morphogenetic protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85272, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmp7provided by RGD
    Official Full Name
    bone morphogenetic protein 7provided by RGD
    Primary source
    RGD:620743
    See related
    EnsemblRapid:ENSRNOG00000053384 AllianceGenome:RGD:620743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BMP-7
    Summary
    Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 205.4), Thymus (RPKM 29.5) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bmp7 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182059318..182135273, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161639915..161716938, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170879972..170955820, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550368 Neighboring gene uncharacterized LOC134486499 Neighboring gene uncharacterized LOC134486500 Neighboring gene SPO11 initiator of meiotic double strand breaks

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP receptor binding  
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity  
    enables heparin binding PubMed 
    enables protein serine/threonine kinase activator activity  
    Items 1 - 25 of 79
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway PubMed 
    involved_in allantois development  
    acts_upstream_of ameloblast differentiation  
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis  
    acts_upstream_of_or_within animal organ morphogenesis  
    acts_upstream_of_or_within axon guidance  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis  
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube  
    acts_upstream_of_or_within camera-type eye morphogenesis  
    involved_in cardiac muscle tissue development  
    involved_in cardiac septum morphogenesis  
    acts_upstream_of_or_within cell development  
    acts_upstream_of cell population proliferation  
    involved_in cellular response to BMP stimulus  
    involved_in chorio-allantoic fusion  
    acts_upstream_of_or_within embryonic camera-type eye morphogenesis  
    acts_upstream_of_or_within embryonic limb morphogenesis  
    acts_upstream_of_or_within embryonic pattern specification  
    acts_upstream_of_or_within embryonic skeletal joint morphogenesis  
    involved_in endocardial cushion formation  
    acts_upstream_of_or_within epithelial cell differentiation  
    involved_in eye development  
    involved_in heart trabecula morphogenesis  
    involved_in hindbrain development  
    acts_upstream_of_or_within kidney development  
    involved_in kidney development  
    acts_upstream_of mesenchymal cell apoptotic process involved in nephron morphogenesis  
    involved_in mesenchymal cell differentiation  
    involved_in mesenchyme development  
    acts_upstream_of_or_within mesoderm formation  
    involved_in mesonephros development  
    involved_in metanephric mesenchymal cell proliferation involved in metanephros development  
    involved_in metanephric mesenchyme morphogenesis  
    involved_in metanephros development  
    involved_in monocyte aggregation  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway  
    involved_in negative regulation of cell cycle  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of glomerular mesangial cell proliferation  
    acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  
    involved_in negative regulation of mitotic nuclear division  
    acts_upstream_of_or_within negative regulation of neurogenesis  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    acts_upstream_of_or_within negative regulation of prostatic bud formation  
    involved_in nephrogenic mesenchyme morphogenesis  
    involved_in neural fold elevation formation  
    acts_upstream_of_or_within neuron projection morphogenesis  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    involved_in osteoblast differentiation  
    acts_upstream_of_or_within pattern specification process  
    involved_in pericardium morphogenesis  
    involved_in pharyngeal system development  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of SMAD protein signal transduction  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of brown fat cell differentiation  
    involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
    involved_in positive regulation of dendrite development  
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of heterotypic cell-cell adhesion  
    involved_in positive regulation of hyaluranon cable assembly  
    acts_upstream_of_or_within positive regulation of neuron differentiation  
    involved_in positive regulation of osteoblast differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis  
    involved_in regulation of phosphorylation PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to vitamin D PubMed 
    acts_upstream_of_or_within salivary gland morphogenesis  
    acts_upstream_of_or_within tube morphogenesis  
    involved_in ureteric bud development  
    Items 1 - 25 of 79
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    bone morphogenetic protein 7
    Names
    bone moorphogenic protein-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191856.3 → NP_001178785.1  bone morphogenetic protein 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001178785.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KKY0, G3V6W8
      Related
      ENSRNOP00000070891.1, ENSRNOT00000084990.4
      Conserved Domains (2) summary
      cd19397
      Location:324 → 430
      TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
      pfam00688
      Location:35 → 279
      TGFb_propeptide; TGF-beta propeptide
    2. NM_001429518.1 → NP_001416447.1  bone morphogenetic protein 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A920

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      182059318..182135273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106002.2 → XP_038961930.1  bone morphogenetic protein 7 isoform X1

      Conserved Domains (2) summary
      cd19397
      Location:258 → 364
      TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
      pfam00688
      Location:35 → 252
      TGFb_propeptide; TGF-beta propeptide
    External link. Please review our privacy policy.