Nek9 NIMA-related kinase 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nek9provided by RGD
Official Full Name: NIMA-related kinase 9provided by RGD
Primary source: RGD:1307187
See related: EnsemblRapid:ENSRNOG00000058572 AllianceGenome:RGD:1307187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in mitotic cell cycle and regulation of mitotic cell cycle. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 248.2), Muscle (RPKM 242.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (110675107..110715586, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (104944056..104984538, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109121524..109162433, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA
enables protein kinase activator activity	ISO
enables protein kinase binding	IBA
enables protein kinase binding	ISO
enables protein serine/threonine kinase activity	ISO

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	ISO
involved_in regulation of mitotic cell cycle	ISO

Component	Evidence Code	Pubs
colocalizes_with centrosome	IBA
located_in centrosome	ISO
located_in cytoplasm	IEA

General protein information

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Preferred Names: serine/threonine-protein kinase Nek9

Names: NIMA (never in mitosis gene a)- related kinase 9

NP_001100217.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106747.2 → NP_001100217.2 serine/threonine-protein kinase Nek9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AQL7, A6JE24

Related

ENSRNOP00000096294.1, ENSRNOT00000106509.2

Conserved Domains (2) summary

COG5184
Location:344 → 687

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd08221
Location:50 → 297

STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

110675107..110715586 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC114701.4	None
genomic	CH473982.1	EDL81568.1
genomic	JAXUCZ010000006.1 (110675107..110715586)	None	BN/NHsdMcwi
mRNA	FQ229156.1	None	Sprague-Dawley