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    Pcdh10 protocadherin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdh10provided by RGD
    Official Full Name
    protocadherin 10provided by RGD
    Primary source
    RGD:1565811
    See related
    EnsemblRapid:ENSRNOG00000031974 AllianceGenome:RGD:1565811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565811
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 120.7) and Adrenal (RPKM 14.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcdh10 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (130553432..130619591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (128617212..128683354)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (136992355..137017705)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 2, pseudogene 6 Neighboring gene uncharacterized LOC120100812 Neighboring gene RAN, member RAS oncogene family, pseudogene 3 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain. Hirano S, et al. J Neurosci, 1999 Feb 1. PMID 9920663, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427768.1 → NP_001414697.1  protocadherin-10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GLZ0, A6KNH5
      Related
      ENSRNOP00000078085.2, ENSRNOT00000099777.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      130553432..130619591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103633.2 → XP_038959561.1  protocadherin-10 isoform X1

      UniProtKB/TrEMBL
      D3ZRX7, F1M6B6
      Related
      ENSRNOP00000042694.4, ENSRNOT00000040187.6
      Conserved Domains (3) summary
      cd11304
      Location:254 → 354
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:19 → 101
      Cadherin_2; Cadherin-like
      pfam16492
      Location:713 → 838
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    2. XM_039103634.2 → XP_038959562.1  protocadherin-10 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YC59, A6KNH6
      Related
      ENSRNOP00000096196.2, ENSRNOT00000113130.2
      Conserved Domains (3) summary
      cd11304
      Location:254 → 354
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:19 → 101
      Cadherin_2; Cadherin-like
      pfam16492
      Location:713 → 838
      Cadherin_C_2; Cadherin cytoplasmic C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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