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    Nsun7 NOP2/Sun RNA methyltransferase family member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsun7provided by RGD
    Official Full Name
    NOP2/Sun RNA methyltransferase family member 7provided by RGD
    Primary source
    RGD:1310137
    See related
    EnsemblRapid:ENSRNOG00000025494 AllianceGenome:RGD:1310137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310137
    Summary
    Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in methylation. Predicted to act upstream of or within flagellated sperm motility and sperm mitochondrion organization. Orthologous to human NSUN7 (NOP2/Sun RNA methyltransferase family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 109.0), Muscle (RPKM 102.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsun7 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42233062..42289013, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (41878562..41935238, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43525530..43584621, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene uncharacterized LOC134481846 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S23 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. Harris T, et al. Biol Reprod, 2007 Aug. PMID 17442852
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative methyltransferase NSUN7
    Names
    NOL1/NOP2/Sun domain family, member 7
    NOP2/Sun domain family, member 7
    Williams-Beuren syndrome critical region protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017452.2 → NP_001017452.1  putative methyltransferase NSUN7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      Q5XIM6

    2. NM_001400916.1 → NP_001387845.1  putative methyltransferase NSUN7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5YC52, A0A8I5ZSS6
      Related
      ENSRNOP00000080300.1, ENSRNOT00000113567.2

    3. NM_001400917.1 → NP_001387846.1  putative methyltransferase NSUN7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JDC1

    4. NM_001400918.1 → NP_001387847.1  putative methyltransferase NSUN7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JDC1, F7EYR2
      Related
      ENSRNOP00000037949.5, ENSRNOT00000039835.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      42233062..42289013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273123.1 → XP_063129193.1  putative methyltransferase NSUN7 isoform X2

      UniProtKB/TrEMBL
      A6JDC1, F7EYR2

    2. XM_006250947.5 → XP_006251009.1  putative methyltransferase NSUN7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC52, A0A8I5ZSS6
      Conserved Domains (1) summary
      COG0144
      Location:313 → 514
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    3. XM_063273125.1 → XP_063129195.1  putative methyltransferase NSUN7 isoform X6

    4. XM_063273124.1 → XP_063129194.1  putative methyltransferase NSUN7 isoform X6

    5. XM_039091913.2 → XP_038947841.1  putative methyltransferase NSUN7 isoform X3

      Conserved Domains (1) summary
      COG0144
      Location:313 → 448
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    6. XM_039091916.2 → XP_038947844.1  putative methyltransferase NSUN7 isoform X7

    7. XM_039091915.2 → XP_038947843.1  putative methyltransferase NSUN7 isoform X5

    8. XM_039091914.2 → XP_038947842.1  putative methyltransferase NSUN7 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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