U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Oxsr1 oxidative stress responsive kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316064, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oxsr1provided by RGD
    Official Full Name
    oxidative stress responsive kinase 1provided by RGD
    Primary source
    RGD:1310466
    See related
    EnsemblRapid:ENSRNOG00000013136 AllianceGenome:RGD:1310466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to osmotic stress; chemokine-mediated signaling pathway; and protein phosphorylation. Predicted to be active in cytosol. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 210.8), Heart (RPKM 206.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Oxsr1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127850481..127941518, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118972754..119062102, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127920349..128009951, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 13-like Neighboring gene solute carrier family 22 member 13-like 1 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 7 Neighboring gene uncharacterized LOC120094290 Neighboring gene MYD88, innate immune signal transduction adaptor Neighboring gene acetyl-CoA acyltransferase 1A Neighboring gene xylulokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables magnesium ion binding  
    enables protein kinase binding  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in cell volume homeostasis  
    involved_in cellular hyperosmotic response  
    involved_in cellular hyperosmotic response  
    involved_in cellular hypotonic response  
    involved_in cellular response to chemokine  
    involved_in chemokine (C-C motif) ligand 21 signaling pathway  
    involved_in chemokine (C-X-C motif) ligand 12 signaling pathway  
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of potassium ion transmembrane transport  
    involved_in negative regulation of potassium ion transmembrane transporter activity  
    involved_in osmosensory signaling pathway  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of T cell chemotaxis  
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation  
    involved_in renal sodium ion absorption  
    involved_in response to oxidative stress  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    serine/threonine-protein kinase OSR1
    Names
    oxidative stress-responsive 1 protein
    oxidative-stress responsive 1
    NP_001101664.1
    XP_063121724.1
    XP_063121725.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108194.1NP_001101664.1  serine/threonine-protein kinase OSR1

      See identical proteins and their annotated locations for NP_001101664.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/Swiss-Prot
      A0A8I5ZNK2, A0A8I5ZZD5
      UniProtKB/TrEMBL
      A6I3V9, D3ZUC9
      Related
      ENSRNOP00000018056.5, ENSRNOT00000018056.7
      Conserved Domains (2) summary
      cd06610
      Location:15291
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
      pfam12202
      Location:434491
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127850481..127941518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265654.1XP_063121724.1  serine/threonine-protein kinase OSR1 isoform X1

      UniProtKB/Swiss-Prot
      A0A8I5ZNK2, A0A8I5ZZD5
    2. XM_063265655.1XP_063121725.1  serine/threonine-protein kinase OSR1 isoform X2

    External link. Please review our privacy policy.