Aldh2 aldehyde dehydrogenase 2 family member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh2provided by RGD
Official Full Name: aldehyde dehydrogenase 2 family memberprovided by RGD
Primary source: RGD:69219
See related: EnsemblRapid:ENSRNOG00000073701 AllianceGenome:RGD:69219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Used to study metabolic dysfunction and alcohol associated liver disease. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1581.0), Adrenal (RPKM 1043.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40610244..40643220)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34949549..34982527)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40466418..40498813)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation.
Title: Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation.
Activation of aldehyde dehydrogenase 2 protects ethanol-induced osteonecrosis of the femoral head in rat model.
Title: Activation of aldehyde dehydrogenase 2 protects ethanol-induced osteonecrosis of the femoral head in rat model.
Mechanism of ALDH2 improves the neuronal damage caused by hypoxia/reoxygenation.
Title: Mechanism of ALDH2 improves the neuronal damage caused by hypoxia/reoxygenation.
ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress.
Title: ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress.
Cardioprotective Effects of PPARbeta/delta Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production.
Title: Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production.
Modulating ALDH2 reveals a differential dependence on ROS for hypertrophy and SR Ca(2+) release in aldosterone-treated cardiac myocytes.
Title: Modulating ALDH2 reveals a differential dependence on ROS for hypertrophy and SR Ca(2+) release in aldosterone-treated cardiac myocytes.
animals jointly receiving nitroglycerin (GTN) and disulfiram (DSF) developed tolerance to GTN, and in animals that in addition to GTN and DSF also received lipoic acid (LA) such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2.
Title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity? A contribution to the ongoing discussion.
Mitochondrial ALDH2 inhibits the proliferation of neonatal rat cardiac fibroblasts induced by high glucose, and the effect is possibly mediated by the up-regulation of autophagy-related proteins Beclin-1 and LC3B.
Title: [Effects of mitochondrial aldehyde dehydrogenase 2 on autophagy-associated proteins in neonatal rat myocardial fibroblasts cultured in high glucose].
increasing ALDH2 activity can improve brain edema, infarct volumes
Title: ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation.
Activation of aldehyde dehydrogenase 2 by low concentration of ethanol can reduce myocardial injury and fibrosis caused by diabetes, and its mechanism may be related to the changes of the two-por potassium channel TASK-1
Title: [Activation of aldehyde dehydrogenase 2 attenuates myocardial injury in diabetic rats by regulating two-pore potassium channel TASK-1].

Submit: New GeneRIF Correction See all GeneRIFs (44)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ALDH2 (e-PCR)
- UniSTS:266605

BI278447 (e-PCR)
- UniSTS:244381

RH131450 (e-PCR)
- UniSTS:214733

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADH binding	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables phenylacetaldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aldehyde catabolic process	ISO Inferred from Sequence Orthology more info
involved_in aldehyde catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic mitochondrial changes	IEP Inferred from Expression Pattern more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification of aldehyde	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to resveratrol	IEP Inferred from Expression Pattern more info	PubMed
involved_in ethanol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ethanol metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitroglycerin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitroglycerin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of serotonin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of serotonin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: aldehyde dehydrogenase, mitochondrial

Names: ALDH class 2; ALDH-E2; ALDH1; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2, mitochondrial; mitochondrial aldehyde dehydrogenase

NP_115792.2

EC 1.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032416.2 → NP_115792.2 aldehyde dehydrogenase, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P11884, Q6Q288, Q6Q289, Q6Q290, Q8K3V8, Q91ZD7

UniProtKB/TrEMBL

A6J1D5, F1LN88

Related

ENSRNOP00000001816.5, ENSRNOT00000001816.8

Conserved Domains (1) summary

cd07141
Location:33 → 513

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like