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    Gng13 G protein subunit gamma 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685451, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gng13provided by RGD
    Official Full Name
    G protein subunit gamma 13provided by RGD
    Primary source
    RGD:1593806
    See related
    EnsemblRapid:ENSRNOG00000039350 AllianceGenome:RGD:1593806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg3j
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to act upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and sensory perception of taste. Predicted to be located in dendrite. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in synapse. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 145.9), Kidney (RPKM 74.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng13 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15245698..15247602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14741179..14743083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15088935..15090839)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC120095315 Neighboring gene chromosome transmission fidelity factor 18 Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene mesothelin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. Huang L, et al. J Comp Neurol, 2003 Jan 1. PMID 12454992
    2. Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3. Zhou JY, et al. J Pharmacol Exp Ther, 2003 May. PMID 12606627
    3. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Huang L, et al. Nat Neurosci, 1999 Dec. PMID 10570481
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Names
    guanine nucleotide binding protein (G protein), gamma 13
    heterotrimeric guanine nucleotide-binding protein 3j

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135918.1 → NP_001129390.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

      See identical proteins and their annotated locations for NP_001129390.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HD38
      Related
      ENSRNOP00000030270.6, ENSRNOT00000030273.6
      Conserved Domains (1) summary
      cd00068
      Location:6 → 61
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15245698..15247602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246034.5 → XP_006246096.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1

      See identical proteins and their annotated locations for XP_006246096.1

      UniProtKB/TrEMBL
      A6HD38
      Conserved Domains (1) summary
      cd00068
      Location:6 → 61
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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