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    Tubb1 tubulin, beta 1 class VI [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679312, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tubb1provided by RGD
    Official Full Name
    tubulin, beta 1 class VIprovided by RGD
    Primary source
    RGD:1589557
    See related
    EnsemblRapid:ENSRNOG00000046151 AllianceGenome:RGD:1589557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including platelet aggregation; platelet formation; and thyroid hormone transport. Predicted to act upstream of or within spindle assembly. Predicted to be located in intercellular bridge and mitotic spindle. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in autosomal dominant isolated macrothrombocytopenia 1. Orthologous to human TUBB1 (tubulin beta 1 class VI). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 162.8), Lung (RPKM 22.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tubb1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (183666189..183675656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (163247990..163257460)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (172550252..172558089)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548488 Neighboring gene GNAS complex locus Neighboring gene negative elongation factor complex member C/D Neighboring gene cathepsin Z Neighboring gene ATP synthase F1 subunit epsilon Neighboring gene PRELI domain containing 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Kunishima S, et al. Blood, 2009 Jan 8. PMID 18849486
    2. A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation. Bhattacharya R, et al. Mol Biol Cell, 2004 Jul. PMID 15121885, Free PMC Article
    3. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin beta-1 chain; tubulin, beta 1 class VI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431729.1 → NP_001418658.1  tubulin, beta 1 class VI

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KL34, M0R8B6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      183666189..183675656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106739.2 → XP_038962667.1  tubulin beta-1 chain isoform X2

      Conserved Domains (1) summary
      PTZ00010
      Location:1 → 355
      PTZ00010; tubulin beta chain; Provisional

    2. XM_003749638.6 → XP_003749686.1  tubulin beta-1 chain isoform X1

      Related
      ENSRNOP00000065711.1, ENSRNOT00000075148.4
      Conserved Domains (2) summary
      PTZ00010
      Location:1 → 428
      PTZ00010; tubulin beta chain; Provisional
      cd02187
      Location:2 → 426
      beta_tubulin; The beta-tubulin family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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