Myh11 myosin heavy chain 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh11provided by RGD
Official Full Name: myosin heavy chain 11provided by RGD
Primary source: RGD:3136
See related: EnsemblRapid:ENSRNOG00000057880 AllianceGenome:RGD:3136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in actin filament organization; cardiac muscle cell development; and elastic fiber assembly. Predicted to act upstream of or within smooth muscle contraction. Predicted to be located in brush border; smooth muscle contractile fiber; and stress fiber. Predicted to be part of muscle myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 2994.9), Lung (RPKM 429.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (1250554..1345681)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (743364..838459)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (764421..859184)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest in vivo function for COOH-terminal isoforms of smooth muscle myosin heavy chains and that isoform ratio it tightly regulated.
Title: Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Rat225 (e-PCR), detects polymorphism
- UniSTS:226335

RH130975 (e-PCR)
- UniSTS:214258

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle myosin complex	ISO Inferred from Sequence Orthology more info
part_of muscle myosin complex	NAS Non-traceable Author Statement more info	PubMed
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-11

Names: SMMHC; myosin heavy chain 21; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; smooth muscle myosin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170600.2 → NP_001164071.1 myosin-11 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A8G7

Related

ENSRNOP00000088033.1, ENSRNOT00000115537.2

Conserved Domains (7) summary

cd14921
Location:99 → 771

MYSc_Myh11; class II myosin heavy chain 11, motor domain

pfam00063
Location:87 → 771

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:990 → 1082

FAM76; FAM76 protein

cl12013
Location:1159 → 1288

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23717
Location:1066 → 1124

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001429924.1 → NP_001416853.1 myosin-11 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A8G7, E9PTU4
NM_001429925.1 → NP_001416854.1 myosin-11 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A8G7, E9PTU4
NM_001429926.1 → NP_001416855.1 myosin-11 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A8G7
NM_001429927.1 → NP_001416856.1 myosin-11 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K6S9, A0A8I6A8G7
NM_001429928.1 → NP_001416857.1 myosin-11 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K6S9, A0A8I6A8G7
NM_001429929.1 → NP_001416858.1 myosin-11 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K6S9, A0A8I6A8G7
NM_001429930.1 → NP_001416859.1 myosin-11 isoform d

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZNN9, A0A8I6A8G7
NM_001429931.1 → NP_001416860.1 myosin-11 isoform d

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZNN9, A0A8I6A8G7
NM_001429932.1 → NP_001416861.1 myosin-11 isoform d

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZNN9, A0A8I6A8G7
NM_001429933.1 → NP_001416862.1 myosin-11 isoform e

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001429934.1 → NP_001416863.1 myosin-11 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

1250554..1345681

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085198.2 → XP_038941126.1 myosin-11 isoform X4

Conserved Domains (3) summary

cd14921
Location:99 → 771

MYSc_Myh11; class II myosin heavy chain 11, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 71

Myosin_N; Myosin N-terminal SH3-like domain
XM_017596998.3 → XP_017452487.1 myosin-11 isoform X3

Related

ENSRNOP00000073929.2, ENSRNOT00000087567.3
XM_006245842.5 → XP_006245904.1 myosin-11 isoform X1

Conserved Domains (7) summary

cd01377
Location:99 → 778

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 778

Myosin_head; Myosin head (motor domain)

pfam01576
Location:855 → 1935

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:997 → 1089

FAM76; FAM76 protein

cl12013
Location:1166 → 1295

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl15254
Location:1049 → 1163

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_063268409.1 → XP_063124479.1 myosin-11 isoform X2
XM_006245844.5 → XP_006245906.1 myosin-11 isoform X1

See identical proteins and their annotated locations for XP_006245906.1

UniProtKB/TrEMBL

A0A8I6A8G7, E9PTU4

Conserved Domains (7) summary

cd01377
Location:99 → 778

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 778

Myosin_head; Myosin head (motor domain)

pfam01576
Location:855 → 1935

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:997 → 1089

FAM76; FAM76 protein

cl12013
Location:1166 → 1295

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl15254
Location:1049 → 1163

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_063268410.1 → XP_063124480.1 myosin-11 isoform X2

UniProtKB/TrEMBL

A0A8I6A8G7
XM_017596997.3 → XP_017452486.1 myosin-11 isoform X1

Related

ENSRNOP00000074575.2, ENSRNOT00000084608.3

Conserved Domains (7) summary

cd01377
Location:99 → 778

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 778

Myosin_head; Myosin head (motor domain)

pfam01576
Location:855 → 1935

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 71

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:997 → 1089

FAM76; FAM76 protein

cl12013
Location:1166 → 1295

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl15254
Location:1049 → 1163

UBAN; polyubiquitin binding domain of NEMO and related proteins