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    Polm DNA polymerase mu [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polmprovided by RGD
    Official Full Name
    DNA polymerase muprovided by RGD
    Primary source
    RGD:1308247
    See related
    EnsemblRapid:ENSRNOG00000013647 AllianceGenome:RGD:1308247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be active in nucleus. Orthologous to human POLM (DNA polymerase mu). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 44.6), Lung (RPKM 31.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polm in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84921039..84930649, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80707075..80716677, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86069378..86079327, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096651 Neighboring gene phosphoglycerate mutase 2 Neighboring gene AE binding protein 1 Neighboring gene DNA polymerase delta 2, accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts. Lucas D, et al. Eur J Immunol, 2005 May. PMID 15789338
    2. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR. Annu Rev Biochem, 2010. PMID 20192759, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed DNA/RNA polymerase mu
    Names
    DNA-directed DNA polymerase mu
    polymerase (DNA directed), mu
    polymerase (DNA) mu
    NP_001011912.1
    XP_006251273.1
    XP_006251274.1
    XP_006251275.1
    XP_006251276.1
    XP_038947670.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011912.1 → NP_001011912.1  DNA-directed DNA/RNA polymerase mu

      See identical proteins and their annotated locations for NP_001011912.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081868
      UniProtKB/TrEMBL
      Q66HH0
      Conserved Domains (2) summary
      cd00141
      Location:156 → 493
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      cl00038
      Location:27 → 123
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84921039..84930649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091742.2 → XP_038947670.1  DNA-directed DNA/RNA polymerase mu isoform X5

      Conserved Domains (2) summary
      cd00141
      Location:85 → 426
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      cl00038
      Location:1 → 52
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

    2. XM_006251211.5 → XP_006251273.1  DNA-directed DNA/RNA polymerase mu isoform X1

      Conserved Domains (2) summary
      cd00141
      Location:176 → 517
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:172 → 518
      POLXc; DNA polymerase X family

    3. XM_006251213.5 → XP_006251275.1  DNA-directed DNA/RNA polymerase mu isoform X3

      Related
      ENSRNOP00000018320.5, ENSRNOT00000018319.8
      Conserved Domains (3) summary
      cd00141
      Location:156 → 497
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:152 → 498
      POLXc; DNA polymerase X family
      cd00027
      Location:30 → 109
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

    4. XM_006251212.5 → XP_006251274.1  DNA-directed DNA/RNA polymerase mu isoform X2

      UniProtKB/TrEMBL
      F7F6Z7
      Conserved Domains (2) summary
      cd00141
      Location:176 → 513
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:172 → 514
      POLXc; DNA polymerase X family

    5. XM_006251214.4 → XP_006251276.1  DNA-directed DNA/RNA polymerase mu isoform X4

      Conserved Domains (2) summary
      cd00141
      Location:94 → 435
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:90 → 436
      POLXc; DNA polymerase X family
    Nucleotide Protein Strain
    Heading Accession and Version

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