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    Dhdds dehydrodolichyl diphosphate synthase subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298541, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dhddsprovided by RGD
    Official Full Name
    dehydrodolichyl diphosphate synthase subunitprovided by RGD
    Primary source
    RGD:1311560
    See related
    EnsemblRapid:ENSRNOG00000014665 AllianceGenome:RGD:1311560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to contribute to dehydrodolichyl diphosphate synthase activity and polyprenyltransferase activity. Predicted to be involved in dolichol biosynthetic process and dolichyl diphosphate biosynthetic process. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 153.0), Kidney (RPKM 90.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhdds in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151482139..151508248, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146198359..146224479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152200681..152227669, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A like 3 Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene lin-28 homolog A Neighboring gene uncharacterized LOC134487000 Neighboring gene zinc finger protein 683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity. Grabińska KA, et al. J Biol Chem, 2017 Oct 20. PMID 28842490, Free PMC Article
    2. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Park EJ, et al. Cell Metab, 2014 Sep 2. PMID 25066056, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to dehydrodolichyl diphosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to dehydrodolichyl diphosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dehydrodolichyl diphosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to polyprenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichyl diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyprenol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of dehydrodolichyl diphosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dehydrodolichyl diphosphate synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrodolichyl diphosphate synthase complex subunit DHDDS
    NP_001011978.1
    XP_063143515.1
    XP_063143516.1
    XP_063143517.1
    XP_063143518.1
    XP_063143519.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011978.1 → NP_001011978.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS

      See identical proteins and their annotated locations for NP_001011978.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085875
      UniProtKB/TrEMBL
      A0A8I6A4U9, F7FA94, Q5U2T2
      Related
      ENSRNOP00000087806.1, ENSRNOT00000118073.2
      Conserved Domains (1) summary
      cd00475
      Location:28 → 248
      Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151482139..151508248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287449.1 → XP_063143519.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X5

    2. XM_063287445.1 → XP_063143515.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4U9
      Related
      ENSRNOP00000020051.6, ENSRNOT00000020051.8

    3. XM_063287448.1 → XP_063143518.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X4

    4. XM_063287446.1 → XP_063143516.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X2

    5. XM_063287447.1 → XP_063143517.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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