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    Srpx sushi-repeat-containing protein, X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srpxprovided by RGD
    Official Full Name
    sushi-repeat-containing protein, X-linkedprovided by RGD
    Primary source
    RGD:70950
    See related
    EnsemblRapid:ENSRNOG00000088892 AllianceGenome:RGD:70950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Drs
    Summary
    Predicted to be involved in phagolysosome assembly. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and response to endoplasmic reticulum stress. Predicted to be located in autophagosome and endoplasmic reticulum. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 89.9), Heart (RPKM 85.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srpx in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (15349498..15420389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (12676984..12751296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (14146618..14220756, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene retinitis pigmentosa GTPase regulator Neighboring gene transfer RNA alanine (anticodon CGC) 4 Neighboring gene synaptotagmin-like 5 Neighboring gene H2A.L variant histone 3 Neighboring gene H2A.P histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel gene down-regulated by v-src. Pan J, et al. FEBS Lett, 1996 Mar 25. PMID 8612783
    2. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Tambe Y, et al. Carcinogenesis, 2007 Apr. PMID 17088259
    3. Expression of drs mRNA in human lung adenocarcinomas. Shimakage M, et al. Hum Pathol, 2002 Jun. PMID 12152160
    4. Isolation of a novel mouse variant of the drs tumor suppressor gene. Kawai T, et al. Cancer Lett, 2002 Sep 8. PMID 12049817
    5. The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. Tambe Y, et al. Cancer Lett, 2009 Sep 28. PMID 19368996

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105430

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell proliferation involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagolysosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phagolysosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sushi repeat-containing protein SRPX
    Names
    down-regulated by v-src
    sushi-repeat-containing protein, X chromosome

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022524.2 → NP_071969.1  sushi repeat-containing protein SRPX precursor

      See identical proteins and their annotated locations for NP_071969.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q5PPK5, Q63769
      UniProtKB/TrEMBL
      A6K020
      Related
      ENSRNOP00000048924.2, ENSRNOT00000045753.4
      Conserved Domains (3) summary
      cd00033
      Location:262 → 317
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:175 → 257
      HYR; HYR domain
      pfam13778
      Location:332 → 449
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      15349498..15420389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256683.5 → XP_006256745.1  sushi repeat-containing protein SRPX isoform X1

      See identical proteins and their annotated locations for XP_006256745.1

      UniProtKB/TrEMBL
      A6K020
      Related
      ENSRNOP00000083955.1, ENSRNOT00000114608.2
      Conserved Domains (3) summary
      cd00033
      Location:242 → 297
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:155 → 237
      HYR; HYR domain
      pfam13778
      Location:312 → 429
      DUF4174; Domain of unknown function (DUF4174)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63769.1 GenPept UniProtKB/Swiss-Prot:Q63769

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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