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    Snap23 synaptosome associated protein 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snap23provided by RGD
    Official Full Name
    synaptosome associated protein 23provided by RGD
    Primary source
    RGD:620221
    See related
    EnsemblRapid:ENSRNOG00000050552 AllianceGenome:RGD:620221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including exocytic insertion of neurotransmitter receptor to postsynaptic membrane; regulation of exocytosis; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of SNARE complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 334.0), Spleen (RPKM 216.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snap23 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127966184..127999929)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107514088..107546177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112333972..112362960)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene codanin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of SNAP-23 regulates exocytosis from mast cells. Hepp R, et al. J Biol Chem, 2005 Feb 25. PMID 15611044
    2. Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells. Naskar P, et al. J Biosci, 2018 Mar. PMID 29485121
    3. Diminished Lipid Raft SNAP23 Increases Blood Pressure by Inhibiting the Membrane Fluidity of Vascular Smooth-Muscle Cells. Yoon MS, et al. J Vasc Res, 2015. PMID 26930561
    4. PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode. Serrano-López EM, et al. Int J Biol Macromol, 2021 Aug 31. PMID 34147527
    5. Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion. Abonyo BO, et al. Biochemistry, 2004 Mar 30. PMID 15035620

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Pathways from PubChem

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    Interactions

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNAP receptor activity PubMed 
    enables protein binding PubMed 
    enables syntaxin binding  
    enables syntaxin binding PubMed 
    enables syntaxin binding  
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane PubMed 
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane PubMed 
    involved_in exocytosis  
    acts_upstream_of_or_within exocytosis  
    involved_in histamine secretion by mast cell  
    involved_in histamine secretion by mast cell  
    involved_in membrane fusion PubMed 
    involved_in protein-containing complex assembly PubMed 
    involved_in regulation of exocytosis PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane  
    involved_in synaptic vesicle priming  
    involved_in vesicle-mediated transport PubMed 
    involved_in vesicle-mediated transport in synapse PubMed 
    involved_in vesicle-mediated transport in synapse PubMed 
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    part_of SNARE complex  
    located_in adherens junction  
    located_in adherens junction  
    located_in azurophil granule  
    located_in azurophil granule  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    is_active_in glutamatergic synapse PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in neuron projection  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    located_in presynapse  
    located_in specific granule  
    located_in specific granule  
    located_in terminal bouton PubMed 
    Items 1 - 20 of 25

    General protein information

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    Preferred Names
    synaptosomal-associated protein 23
    Names
    SNAP-23
    synaptosomal-associated protein, 23 kD
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429469.1 → NP_001416398.1  synaptosomal-associated protein 23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      M0R4V3

    2. NM_001429470.1 → NP_001416399.1  synaptosomal-associated protein 23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A0JPL8, O70377

    3. NM_022689.2 → NP_073180.1  synaptosomal-associated protein 23 isoform 1

      See identical proteins and their annotated locations for NP_073180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127494
      UniProtKB/Swiss-Prot
      A0JPL8, O70377
      Related
      ENSRNOP00000091304.1, ENSRNOT00000096953.2
      Conserved Domains (3) summary
      cd15884
      Location:148 → 206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86 → 146
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127966184..127999929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105811.2 → XP_038961739.1  synaptosomal-associated protein 23 isoform X1

      Related
      ENSRNOP00000064401.3, ENSRNOT00000074392.4
      Conserved Domains (3) summary
      cd15884
      Location:159 → 217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 157
      SNAP-25; SNAP-25 family

    2. XM_039105813.2 → XP_038961741.1  synaptosomal-associated protein 23 isoform X2

      Conserved Domains (3) summary
      cd15884
      Location:148 → 206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86 → 146
      SNAP-25; SNAP-25 family

    3. XM_063284525.1 → XP_063140595.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      A0JPL8, O70377

    4. XM_039105812.2 → XP_038961740.1  synaptosomal-associated protein 23 isoform X1

      UniProtKB/TrEMBL
      M0R4V3
      Conserved Domains (3) summary
      cd15884
      Location:159 → 217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 157
      SNAP-25; SNAP-25 family

    5. XM_063284526.1 → XP_063140596.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      A0JPL8, O70377
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70377.1 GenPept UniProtKB/Swiss-Prot:O70377

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