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    Arfgap1 ARF GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246310, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arfgap1provided by RGD
    Official Full Name
    ARF GTPase activating protein 1provided by RGD
    Primary source
    RGD:708452
    See related
    EnsemblRapid:ENSRNOG00000043150 AllianceGenome:RGD:708452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arf1gap; Arf GAP1
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of endocytosis. Located in Golgi membrane. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 153.2), Muscle (RPKM 148.9) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arfgap1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188462125..188477515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168084560..168099948)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176475847..176490642)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene Sodium/potassium transporting ATPase interacting 4 Neighboring gene collagen type XX alpha 1 chain Neighboring gene cholinergic receptor nicotinic alpha 4 subunit Neighboring gene potassium voltage-gated channel subfamily Q member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in protein transport  
    involved_in regulation of ARF protein signal transduction  
    involved_in regulation of endocytosis  
    acts_upstream_of_or_within regulation of endocytosis  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    is_active_in Golgi membrane  
    located_in Golgi membrane PubMed 
    located_in postsynaptic density  
    located_in synapse  
    is_active_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 1
    Names
    ADP-ribosylation factor 1 GTPase-activating protein
    ADP-ribosylation factor GTPase activating protein 1
    ARF GAP 1
    ARF1 GAP
    ARF1-directed GTPase-activating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145090.4NP_659558.1  ADP-ribosylation factor GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_659558.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62848
      UniProtKB/TrEMBL
      A0A0H2UHZ3, A6KM64
      Conserved Domains (1) summary
      cd08830
      Location:6121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188462125..188477515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235732.4XP_006235794.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006235794.1

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A4
      Related
      ENSRNOP00000013900.5, ENSRNOT00000013900.8
      Conserved Domains (2) summary
      pfam01412
      Location:7114
      ArfGap; Putative GTPase activating protein for Arf
      pfam13257
      Location:325376
      DUF4048; Domain of unknown function (DUF4048)
    2. XM_063283084.1XP_063139154.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHZ3
    3. XM_063283085.1XP_063139155.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A5
    4. XM_063283087.1XP_063139157.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHZ3
      Related
      ENSRNOP00000073451.2, ENSRNOT00000082267.3
    5. XM_063283089.1XP_063139159.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A0H2UHZ3
    6. XM_006235731.4XP_006235793.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006235793.1

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A4
      Conserved Domains (2) summary
      pfam01412
      Location:7114
      ArfGap; Putative GTPase activating protein for Arf
      pfam13257
      Location:325376
      DUF4048; Domain of unknown function (DUF4048)
    7. XM_063283086.1XP_063139156.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHZ3, Q3S4A5
    8. XM_063283088.1XP_063139158.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHZ3
    9. XM_063283090.1XP_063139160.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A0H2UHZ3
    10. XM_039104259.2XP_038960187.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q62848
      UniProtKB/TrEMBL
      A0A0H2UHZ3, A6KM64
      Related
      ENSRNOP00000051916.5, ENSRNOT00000055038.5
      Conserved Domains (1) summary
      cd08830
      Location:6121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1
    11. XM_063283091.1XP_063139161.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X7

    RNA

    1. XR_010064557.1 RNA Sequence

    2. XR_010064559.1 RNA Sequence

    3. XR_010064560.1 RNA Sequence

    4. XR_010064558.1 RNA Sequence

    5. XR_010064561.1 RNA Sequence

    6. XR_010064562.1 RNA Sequence

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