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    Slc9a1 solute carrier family 9 member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24782, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc9a1provided by RGD
    Official Full Name
    solute carrier family 9 member A1provided by RGD
    Primary source
    RGD:3718
    See related
    EnsemblRapid:ENSRNOG00000007982 AllianceGenome:RGD:3718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nhe1
    Summary
    Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to insulin stimulus; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 66.7), Adrenal (RPKM 51.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc9a1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150859412..150913525)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145576341..145629630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151573122..151626360)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487005 Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134487006 Neighboring gene uncharacterized LOC134487001 Neighboring gene uncharacterized LOC134479037

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables calmodulin binding  
    enables identical protein binding  
    enables phospholipid binding  
    enables potassium:proton antiporter activity  
    enables protein binding PubMed 
    enables protein phosphatase 2B binding  
    enables sodium:proton antiporter activity  
    enables sodium:proton antiporter activity PubMed 
    enables sodium:proton antiporter activity PubMed 
    enables sodium:proton antiporter activity  
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in cardiac muscle cell contraction PubMed 
    acts_upstream_of_or_within cardiac muscle cell differentiation  
    involved_in cell differentiation PubMed 
    involved_in cellular response to acidic pH  
    involved_in cellular response to acidic pH  
    involved_in cellular response to antibiotic PubMed 
    involved_in cellular response to cold PubMed 
    involved_in cellular response to electrical stimulus PubMed 
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in intracellular sodium ion homeostasis  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in positive regulation of action potential PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of calcium:sodium antiporter activity  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of intracellular signal transduction PubMed 
    involved_in positive regulation of mitochondrial membrane permeability PubMed 
    involved_in positive regulation of the force of heart contraction  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in potassium ion transmembrane transport  
    involved_in proton transmembrane transport  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling  
    involved_in regulation of intracellular pH  
    involved_in regulation of intracellular pH PubMed 
    involved_in regulation of intracellular pH  
    involved_in regulation of intracellular pH  
    acts_upstream_of_or_within regulation of pH  
    involved_in regulation of pH  
    involved_in regulation of pH  
    involved_in regulation of the force of heart contraction PubMed 
    involved_in regulation of the force of heart contraction by cardiac conduction  
    involved_in response to acidic pH PubMed 
    acts_upstream_of_or_within response to acidic pH  
    involved_in response to acidic pH  
    involved_in response to acidic pH  
    involved_in response to muscle stretch  
    involved_in response to organic cyclic compound PubMed 
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion import across plasma membrane  
    involved_in sodium ion import across plasma membrane  
    acts_upstream_of_or_within sodium ion transport  
    acts_upstream_of_or_within stem cell differentiation  
    Items 1 - 25 of 47
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    part_of cation-transporting ATPase complex  
    located_in cell surface PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intercalated disc PubMed 
    located_in membrane  
    located_in membrane raft  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in sarcolemma PubMed 
    part_of transporter complex  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 1
    Names
    NHE-1
    Na(+)/H(+) exchanger 1
    Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)
    solute carrier family 9 (sodium/hydrogen exchanger), member 1
    solute carrier family 9 member 1
    solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012652.2NP_036784.1  sodium/hydrogen exchanger 1

      See identical proteins and their annotated locations for NP_036784.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P26431
      UniProtKB/TrEMBL
      A6ISW5
      Related
      ENSRNOP00000011049.2, ENSRNOT00000011049.6
      Conserved Domains (3) summary
      TIGR00840
      Location:99664
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:109507
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:606704
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      150859412..150913525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287163.1XP_063143233.1  sodium/hydrogen exchanger 1 isoform X1

    2. XM_063287164.1XP_063143234.1  sodium/hydrogen exchanger 1 isoform X2

    RNA

    1. XR_005504368.2 RNA Sequence

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