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    Mpc2 mitochondrial pyruvate carrier 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359982, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpc2provided by RGD
    Official Full Name
    mitochondrial pyruvate carrier 2provided by RGD
    Primary source
    RGD:1563422
    See related
    EnsemblRapid:ENSRNOG00000003150 AllianceGenome:RGD:1563422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brp44; SLC54A2; RGD1563422
    Summary
    Predicted to enable identical protein binding activity and pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within acetyl-CoA biosynthetic process from pyruvate and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1056.6), Kidney (RPKM 874.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mpc2 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80261143..80280668)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77728176..77747664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83680527..83700491)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene uncharacterized LOC134481587 Neighboring gene adenylate cyclase 10 Neighboring gene uncharacterized LOC134481588

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion  

    General protein information

    Preferred Names
    mitochondrial pyruvate carrier 2
    Names
    brain protein 44
    protein 0-44
    solute carrier family 54 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077643.2NP_001071111.1  mitochondrial pyruvate carrier 2 isoform 1

      See identical proteins and their annotated locations for NP_001071111.1

      Status: VALIDATED

      Source sequence(s)
      FM061478, JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P38718
      UniProtKB/TrEMBL
      A6IDH0
      Related
      ENSRNOP00000004206.6, ENSRNOT00000004206.9
      Conserved Domains (1) summary
      pfam03650
      Location:33122
      MPC; Uncharacterized protein family (UPF0041)
    2. NM_001322942.1NP_001309871.1  mitochondrial pyruvate carrier 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AS07, A6IDG9
      Related
      ENSRNOP00000094616.1, ENSRNOT00000098110.2
      Conserved Domains (1) summary
      pfam03650
      Location:3381
      MPC; Uncharacterized protein family (UPF0041)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80261143..80280668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250126.4XP_006250188.1  mitochondrial pyruvate carrier 2 isoform X1

      UniProtKB/Swiss-Prot
      P38718
      Conserved Domains (1) summary
      pfam03650
      Location:33114
      MPC; Uncharacterized protein family (UPF0041)
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