Dynll2 dynein light chain LC8-type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dynll2provided by RGD
Official Full Name: dynein light chain LC8-type 2provided by RGD
Primary source: RGD:619860
See related: EnsemblRapid:ENSRNOG00000008921 AllianceGenome:RGD:619860
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlc2
Summary: Enables identical protein binding activity and scaffold protein binding activity. Predicted to be involved in microtubule-based process. Part of cytoplasmic dynein complex. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 493.0), Heart (RPKM 303.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (73264260..73283042, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (72767035..72785824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (75262536..75281302, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that feeding increases excitatory synaptic input on paraventricular nucleus oxytocin neurons via mechanisms involving DYNLL2 upregulation and NMDA receptor-mediated synaptic reorganization.
Title: Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus.
Data show that Bassoon functions as a cargo adapter for retrograde transport and that disruption of the Bassoon-dynein light chain 1/2 interactions leads to impaired trafficking of Bassoon and affects distribution of Bassoon and Piccolo among synapses.
Title: Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Chm200 (e-PCR)
- UniSTS:518172

C87222 (e-PCR)
- UniSTS:208725

RH127756 (e-PCR)
- UniSTS:211066

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of myosin V complex	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein light chain 2, cytoplasmic

Names: dynein light chain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080697.2 → NP_542428.1 dynein light chain 2, cytoplasmic

See identical proteins and their annotated locations for NP_542428.1

Status: PROVISIONAL

Source sequence(s)

BC061874

UniProtKB/Swiss-Prot

Q78P75

UniProtKB/TrEMBL

A6HHW6

Related

ENSRNOP00000012279.3, ENSRNOT00000012279.6

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

73264260..73283042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247077.4 → XP_006247139.1 dynein light chain 2, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_006247139.1

UniProtKB/Swiss-Prot

Q78P75

UniProtKB/TrEMBL

A6HHW6

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
XM_039085093.2 → XP_038941021.1 dynein light chain 2, cytoplasmic isoform X1

UniProtKB/Swiss-Prot

Q78P75

UniProtKB/TrEMBL

A6HHW6

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
XM_063268351.1 → XP_063124421.1 dynein light chain 2, cytoplasmic isoform X1

UniProtKB/Swiss-Prot

Q78P75

UniProtKB/TrEMBL

A6HHW6