Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zrsr2provided by RGD
Official Full Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2provided by RGD
Primary source: RGD:1559763
See related: EnsemblRapid:ENSRNOG00000033176 AllianceGenome:RGD:1559763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559763
Summary: Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex and U2AF complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 56.7), Thymus (RPKM 40.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (34179279..34201989)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30547424..30571613)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (32304707..32327419)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 3'-splice site binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA 3'-splice site binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2AF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427289.1 → NP_001414218.1 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

D3ZHQ8

Related

ENSRNOP00000049816.5, ENSRNOT00000045300.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

34179279..34201989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256887.5 → XP_006256949.1 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

See identical proteins and their annotated locations for XP_006256949.1

UniProtKB/TrEMBL

D3ZHQ8

Conserved Domains (3) summary

smart00356
Location:306 → 331

ZnF_C3H1; zinc finger

cd12540
Location:199 → 303

RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

pfam00642
Location:167 → 191

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)