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    Ap3b2 adaptor related protein complex 3 subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308777, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ap3b2provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit beta 2provided by RGD
    Primary source
    RGD:1308950
    See related
    EnsemblRapid:ENSRNOG00000019249 AllianceGenome:RGD:1308950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Predicted to be active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 197.1), Uterus (RPKM 19.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Ap3b2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144821819..144854533, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135412580..135445191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143284041..143315846, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene uncharacterized LOC134483747 Neighboring gene uncharacterized LOC134483748 Neighboring gene uncharacterized LOC102555928 Neighboring gene cDNA sequence BC048679-like Neighboring gene small Cajal body-specific RNA 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in presynapse  

    General protein information

    Preferred Names
    AP-3 complex subunit beta-2
    Names
    adaptor-related protein complex 3, beta 2 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107532.2NP_001101002.2  AP-3 complex subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      FQ085944, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JCF9
      Related
      ENSRNOP00000107834.1, ENSRNOT00000026030.9
      Conserved Domains (3) summary
      sd00044
      Location:111139
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:34590
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:804947
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144821819..144854533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262715.1XP_063118785.1  AP-3 complex subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A6JCF9
    2. XM_063262713.1XP_063118783.1  AP-3 complex subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A6JCF9
    3. XM_063262712.1XP_063118782.1  AP-3 complex subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A6JCF9
      Related
      ENSRNOP00000098987.1, ENSRNOT00000159502.1
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