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    Fzd5 frizzled class receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317674, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd5provided by RGD
    Official Full Name
    frizzled class receptor 5provided by RGD
    Primary source
    RGD:631406
    See related
    EnsemblRapid:ENSRNOG00000014678 AllianceGenome:RGD:631406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Wnt-protein binding activity. Involved in presynapse assembly. Is active in glutamatergic synapse. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Fzd5 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73606860..73614039, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66113096..66120276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71443784..71445541, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094695 Neighboring gene uncharacterized LOC134480380 Neighboring gene cyclin Y-like 1 Neighboring gene basic proline-rich protein-like Neighboring gene pleckstrin homology domain containing M3 Neighboring gene uncharacterized LOC120094696 Neighboring gene crystallin, gamma E

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables Wnt-protein binding PubMed 
    enables Wnt-protein binding  
    enables amyloid-beta binding  
    enables amyloid-beta binding  
    enables lipid binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 68
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in Spemann organizer formation  
    involved_in Spemann organizer formation  
    involved_in T cell differentiation in thymus  
    acts_upstream_of_or_within T cell differentiation in thymus  
    acts_upstream_of_or_within Wnt signaling pathway  
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in anterior/posterior axis specification, embryo  
    involved_in anterior/posterior axis specification, embryo  
    involved_in apoptotic process involved in morphogenesis  
    acts_upstream_of_or_within apoptotic process involved in morphogenesis  
    involved_in biological_process  
    involved_in branching involved in labyrinthine layer morphogenesis  
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in cellular response to molecule of bacterial origin  
    involved_in cellular response to molecule of bacterial origin  
    involved_in chorionic trophoblast cell differentiation  
    acts_upstream_of_or_within chorionic trophoblast cell differentiation  
    involved_in embryonic axis specification  
    acts_upstream_of_or_within embryonic camera-type eye development  
    involved_in embryonic camera-type eye morphogenesis  
    involved_in embryonic camera-type eye morphogenesis  
    involved_in eye development  
    involved_in eye development  
    involved_in glandular epithelial cell maturation  
    acts_upstream_of_or_within glandular epithelial cell maturation  
    involved_in intestinal epithelial cell maturation  
    acts_upstream_of_or_within intestinal epithelial cell maturation  
    involved_in labyrinthine layer blood vessel development  
    acts_upstream_of_or_within labyrinthine layer blood vessel development  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in non-canonical Wnt signaling pathway  
    involved_in non-canonical Wnt signaling pathway  
    involved_in non-canonical Wnt signaling pathway  
    involved_in non-canonical Wnt signaling pathway  
    acts_upstream_of_or_within positive regulation of JUN kinase activity  
    involved_in positive regulation of T cell cytokine production  
    involved_in positive regulation of T cell cytokine production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of protein targeting to mitochondrion PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    involved_in positive regulation of type II interferon production  
    involved_in post-embryonic camera-type eye development  
    acts_upstream_of_or_within post-embryonic camera-type eye development  
    involved_in post-embryonic camera-type eye development  
    involved_in presynapse assembly PubMed 
    involved_in presynapse assembly PubMed 
    involved_in presynapse assembly PubMed 
    involved_in regulation of bicellular tight junction assembly  
    acts_upstream_of_or_within regulation of bicellular tight junction assembly  
    involved_in regulation of chorionic trophoblast cell proliferation  
    acts_upstream_of_or_within regulation of chorionic trophoblast cell proliferation  
    involved_in regulation of mitophagy PubMed 
    involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development  
    acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development  
    acts_upstream_of_or_within vasculature development  
    Items 1 - 25 of 68
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in axon  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in cell surface  
    located_in cell surface  
    located_in dendrite  
    located_in early endosome  
    located_in early endosome  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in synapse PubMed 
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    frizzled-5
    Names
    frizzled family receptor 5
    fz-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173838.3NP_776210.2  frizzled-5 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q8CHL0
      UniProtKB/TrEMBL
      A0A0G2JXX8, A6IPI5
      Related
      ENSRNOP00000099774.1, ENSRNOT00000154504.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73606860..73614039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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