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    Mtap methylthioadenosine phosphorylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtapprovided by RGD
    Official Full Name
    methylthioadenosine phosphorylaseprovided by RGD
    Primary source
    RGD:1310114
    See related
    EnsemblRapid:ENSRNOG00000006615 AllianceGenome:RGD:1310114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cc1-6
    Summary
    Enables S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 82.4), Adrenal (RPKM 74.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtap in Genome Data Viewer
    Location:
    5q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (108990270..109036494)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103874460..103920684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (107711077..107777530)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350998 Neighboring gene similar to human chromosome 9 open reading frame 85 Neighboring gene ARL14 effector protein-like Neighboring gene RNA N6-adenosine-methyltransferase METTL16-like Neighboring gene GSK3B interacting protein, pseudogene 1 Neighboring gene cyclin-dependent kinase inhibitor 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Label-free LC-MS/MS shotgun proteomics to investigate the anti-inflammatory effect of rCC16. Pang M, et al. Mol Med Rep, 2016 Nov. PMID 27748820, Free PMC Article
    2. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Karikari CA, et al. Mol Cancer Ther, 2005 Dec. PMID 16373701
    3. Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate. Seidenfeld J, et al. Biochem Biophys Res Commun, 1980 Aug 29. PMID 6774734
    4. The stimulatory effect of testosterone propionate and 17 beta-estradiol on 5'-methylthioadenosine phosphorylase activity in rat target tissues. Nicolette JA, et al. Biochim Biophys Acta, 1980 Jan 17. PMID 6766069
    5. Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme. Abbruzzese A, et al. J Neurochem, 1983 Feb. PMID 6401802

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-methyl-5-thioadenosine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in nicotinamide riboside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S-methyl-5'-thioadenosine phosphorylase
    Names
    5'-methylthioadenosine phosphorylase
    NP_001380978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394049.1 → NP_001380978.1  S-methyl-5'-thioadenosine phosphorylase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K583, A6JRF0
      Related
      ENSRNOP00000073330.1, ENSRNOT00000090739.3
      Conserved Domains (1) summary
      cd09010
      Location:12 → 255
      MTAP_SsMTAPII_like_MTIP; 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      108990270..109036494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047867.1: Suppressed sequence

      Description
      NM_001047867.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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