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    Cabyr calcium binding tyrosine phosphorylation regulated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cabyrprovided by RGD
    Official Full Name
    calcium binding tyrosine phosphorylation regulatedprovided by RGD
    Primary source
    RGD:1585413
    See related
    EnsemblRapid:ENSRNOG00000047436 AllianceGenome:RGD:1585413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; enzyme binding activity; and protein domain specific binding activity. Predicted to be involved in sperm capacitation. Predicted to be located in cytosol; nucleoplasm; and sperm flagellum. Predicted to be active in cytoplasm and sperm fibrous sheath. Orthologous to human CABYR (calcium binding tyrosine phosphorylation regulated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 146.6), Brain (RPKM 80.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cabyr in Genome Data Viewer
    Location:
    18p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4166790..4178570)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3892062..3904391)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4082175..4096650)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482905 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene uncharacterized LOC134482904 Neighboring gene oxysterol binding protein-like 1A Neighboring gene uncharacterized LOC102546723 Neighboring gene oxysterol binding protein-like 1A like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Splicing in murine CABYR and its genomic structure. Sen B, et al. Gene, 2003 May 22. PMID 12801634
    2. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. Naaby-Hansen S, et al. Dev Biol, 2002 Feb 15. PMID 11820818
    3. Expression of the sperm fibrous sheath protein CABYR in human cancers and identification of α-enolase as an interacting partner of CABYR-a. Tseng YT, et al. Oncol Rep, 2011 Apr. PMID 21274509
    4. CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Li YF, et al. Reprod Biol Endocrinol, 2010 Aug 23. PMID 20731842, Free PMC Article
    5. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. Newell AE, et al. Cell Motil Cytoskeleton, 2008 Jul. PMID 18421703

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in sperm capacitation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm end piece ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding tyrosine phosphorylation-regulated protein
    Names
    calcium binding tyrosine-(Y)-phosphorylation regulated
    calcium-binding tyrosine-phosphorylation regulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143893.2 → NP_001137365.1  calcium-binding tyrosine phosphorylation-regulated protein

      See identical proteins and their annotated locations for NP_001137365.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KLS1, M0R8P3
      Related
      ENSRNOP00000065843.1, ENSRNOT00000071392.3
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      4166790..4178570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254426.5 → XP_006254488.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

      See identical proteins and their annotated locations for XP_006254488.1

      UniProtKB/TrEMBL
      A6KLR9
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    2. XM_039097129.2 → XP_038953057.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMY5, A6KLS0
      Related
      ENSRNOP00000079211.1, ENSRNOT00000094472.2
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    3. XM_063277594.1 → XP_063133664.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

    4. XM_063277595.1 → XP_063133665.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X4

    RNA

    1. XR_001842032.3 RNA Sequence

    2. XR_010059601.1 RNA Sequence

    3. XR_010059602.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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