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    Unc93b1 unc-93 homolog B1, TLR signaling regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc93b1provided by RGD
    Official Full Name
    unc-93 homolog B1, TLR signaling regulatorprovided by RGD
    Primary source
    RGD:1311984
    See related
    EnsemblRapid:ENSRNOG00000017703 AllianceGenome:RGD:1311984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc93b
    Summary
    Predicted to enable Toll-like receptor binding activity. Predicted to be involved in endolysosomal toll-like receptor signaling pathway and intracellular protein transport. Predicted to act upstream of or within several processes, including T cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; and positive regulation of cytokine production. Predicted to be located in early phagosome and endoplasmic reticulum. Predicted to be active in endosome and lysosome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human UNC93B1 (unc-93 homolog B1, TLR signaling regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 497.9), Lung (RPKM 149.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc93b1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210596639..210607579)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201167388..201178343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219172987..219183941)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Koehn J, et al. Hum Immunol, 2007 Nov. PMID 18082565
    2. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. Caetano BC, et al. J Immunol, 2011 Aug 15. PMID 21753151, Free PMC Article
    3. BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells. Defays A, et al. Blood, 2011 Jul 21. PMID 21642595
    4. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Isnardi I, et al. Immunity, 2008 Nov 14. PMID 19006693, Free PMC Article
    5. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Eidenschenk C, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457904, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
      Title: Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Toll-like receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Toll-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 3 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 7 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 9 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in early phagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-93 homolog B1
    Names
    unc-93 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403514.1 → NP_001390443.1  protein unc-93 homolog B1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYP4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210596639..210607579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589435.2 → XP_017444924.1  protein unc-93 homolog B1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSD6
      Related
      ENSRNOP00000081147.2, ENSRNOT00000110255.2

    2. XM_039083685.1 → XP_038939613.1  protein unc-93 homolog B1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW71, D3ZDJ4
      Related
      ENSRNOP00000024018.5, ENSRNOT00000024018.8
      Conserved Domains (1) summary
      cd17408
      Location:54 → 510
      MFS_unc93B1; Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108513.1: Suppressed sequence

      Description
      NM_001108513.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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