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    Asb9 ankyrin repeat and SOCS box-containing 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb9provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 9provided by RGD
    Primary source
    RGD:1560537
    See related
    EnsemblRapid:ENSRNOG00000067365 AllianceGenome:RGD:1560537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560537
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in membrane. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ASB9 (ankyrin repeat and SOCS box containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 87.5) and Kidney (RPKM 47.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb9 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33588484..33633285, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (29956576..30001436, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31700637..31745790, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene ankyrin repeat and SOCS box containing 11 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. Debrincat MA, et al. J Biol Chem, 2007 Feb 16. PMID 17148442
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 9
    Names
    ankyrin repeat and SOCS box-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191913.2 → NP_001178842.1  ankyrin repeat and SOCS box protein 9

      See identical proteins and their annotated locations for NP_001178842.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1M6U5
      Related
      ENSRNOP00000038983.6, ENSRNOT00000041515.7
      Conserved Domains (4) summary
      PLN03192
      Location:27 → 214
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:31 → 62
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:36 → 122
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:249 → 290
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33588484..33633285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602120.3 → XP_017457609.1  ankyrin repeat and SOCS box protein 9 isoform X1

      Conserved Domains (4) summary
      PLN03192
      Location:27 → 214
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:31 → 62
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:36 → 122
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:249 → 290
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    Nucleotide Protein Strain
    Heading Accession and Version

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