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    Nmt2 N-myristoyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmt2provided by RGD
    Official Full Name
    N-myristoyltransferase 2provided by RGD
    Primary source
    RGD:1303175
    See related
    EnsemblRapid:ENSRNOG00000026248 AllianceGenome:RGD:1303175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and protein localization to membrane. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 249.4), Adrenal (RPKM 227.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmt2 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79826999..79874088, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74917833..74964788, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78919235..78966013, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482748 Neighboring gene U4 spliceosomal RNA Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene uncharacterized LOC134482749 Neighboring gene uncharacterized LOC134482750 Neighboring gene integrin subunit alpha 8 Neighboring gene uncharacterized LOC120097958

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis. Sun Y, et al. J Psychiatr Res, 2024 Aug. PMID 38852542
    2. Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases. Rioux V, et al. Mol Cell Biochem, 2006 Jun. PMID 16538398
    3. Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2. Kolluri SK, et al. Cancer Res, 2001 Dec 1. PMID 11731439
    4. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Thinon E, et al. Nat Commun, 2014 Sep 26. PMID 25255805, Free PMC Article
    5. A second mammalian N-myristoyltransferase. Giang DK, et al. J Biol Chem, 1998 Mar 20. PMID 9506952

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
      Title: NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
    2. NMT2 protein exhibited functional myristoyltransferase activity, but appeared to be 4-time less active than NMT1.
      Title: Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptidyl-lysine N6-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glycine N-myristoylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in N-terminal protein myristoylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    NP_001399348.1
    NP_997473.2
    XP_008770076.1
    XP_017455983.1
    XP_038951470.1
    XP_063132313.1
    XP_063132314.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412419.1 → NP_001399348.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A8X5, F1M110
      Related
      ENSRNOP00000035716.6, ENSRNOT00000030228.7

    2. NM_207590.2 → NP_997473.2  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6JM25, Q700Q7
      Related
      ENSRNOP00000078750.2, ENSRNOT00000112511.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      79826999..79874088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276243.1 → XP_063132313.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8X5

    2. XM_017600494.3 → XP_017455983.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8X5

    3. XM_039095542.2 → XP_038951470.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8X5
      Conserved Domains (1) summary
      COG5092
      Location:125 → 492
      NMT1; N-myristoyl transferase [Lipid metabolism]

    4. XM_063276244.1 → XP_063132314.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLL5, A0A8I5ZWZ4
      Related
      ENSRNOP00000083953.1, ENSRNOT00000119939.2

    5. XM_008771854.4 → XP_008770076.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8X5, A0A8I6A9A8
      Related
      ENSRNOP00000090038.1, ENSRNOT00000099682.2
      Conserved Domains (2) summary
      pfam01233
      Location:144 → 298
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:314 → 489
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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