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    Setd1a SET domain containing 1A, histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309001, updated on 9-Dec-2024

    Summary

    Official Symbol
    Setd1aprovided by RGD
    Official Full Name
    SET domain containing 1A, histone lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1311624
    See related
    EnsemblRapid:ENSRNOG00000055028 AllianceGenome:RGD:1311624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311624
    Summary
    Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; beta-catenin binding activity; and histone H3K4 methyltransferase activity. Predicted to be involved in several processes, including regulation of chromatin organization; regulation of erythrocyte differentiation; and regulation of hematopoietic stem cell differentiation. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; and stem cell population maintenance. Predicted to be located in cytoplasm; euchromatin; and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Human ortholog(s) of this gene implicated in early-onset epilepsy 2 and neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 45.6), Thymus (RPKM 44.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Setd1a in Genome Data Viewer
    Location:
    1q37
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191818752..191842167)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182386197..182411695)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199222584..199247993)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 19 Neighboring gene uncharacterized LOC134483922 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC134483916

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex  
    part_of Set1C/COMPASS complex  
    located_in chromatin  
    located_in cytoplasm  
    located_in euchromatin  
    part_of histone methyltransferase complex  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus  

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SETD1A
    NP_001414023.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427094.1NP_001414023.1  histone-lysine N-methyltransferase SETD1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K6T6, A0A8I6AS32
      Related
      ENSRNOP00000073937.1, ENSRNOT00000088606.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191818752..191842167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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