Spink1 serine peptidase inhibitor, Kazal type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spink1provided by RGD
Official Full Name: serine peptidase inhibitor, Kazal type 1provided by RGD
Primary source: RGD:3749
See related: EnsemblRapid:ENSRNOG00000068869 AllianceGenome:RGD:3749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tilp; Psti-1; Spink3; PSTI-61
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; positive regulation of secretion; and response to ethanol. Located in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 511.2), Liver (RPKM 482.9) and 1 other tissue See more
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Genomic context

Location:: 18q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (36121626..36133596, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (35870723..35882693, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (38221919..38242092, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPINK3 along with Ccna2 and EGFR accelerated cell proliferation during rat liver regeneration via P38 MAPK, PKC, JAK-STAT and AKT pathways.
Title: [SPINK3: A novel growth factor that promotes rat liver regeneration].
This study created a novel mouse model of mtDNA depletion by expressing relatively low levels of mito-PstI in CNS neurons, which leads to a chronic OXPHOS deficiency.
Title: The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions.
severity of chronic pancreatitis and pancreatic fibrosis is significantly reduced in mice expressing rat PSTI-I; propose that endogenous pancreatic trypsin inhibitors play a protective role in the pancreatic response to repeated injurious events
Title: Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
Caltrin protein modulates the acrosomal exocytosis during sperm capacitation.
Title: Rat caltrin protein modulates the acrosomal exocytosis during sperm capacitation.
Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.
Title: Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.
dual function: monitoring protein in gut due to its 'moderate' affinity for trypsin and a protective role in pancreas
Title: The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Arb2 (e-PCR)
- UniSTS:240314

D18Wox9 (e-PCR)
- UniSTS:240350

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pancreatic juice secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptide hormone secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sperm capacitation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 1

Names: PSTI-I; Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic; cholecystokinin-releasing peptide; monitor peptide; pancreatic cholecystokinin(CCK) releasing peptide; pancreatic secretory trypsin inhibitor I; pancreatic secretory trypsin inhibitor-61; serine peptidase inhibitor, Kazal type 3; trypsin inhibitor-like protein, pancreatic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012674.2 → NP_036806.1 serine protease inhibitor Kazal-type 1 precursor

See identical proteins and their annotated locations for NP_036806.1

Status: VALIDATED

Source sequence(s)

M27882, X59696

UniProtKB/Swiss-Prot

P09655, P13072

UniProtKB/TrEMBL

A6KUD5

Related

ENSRNOP00000095930.1, ENSRNOT00000095851.2

Conserved Domains (1) summary

cd01327
Location:38 → 79

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...