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    Egfl6 EGF-like-domain, multiple 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Egfl6provided by RGD
    Official Full Name
    EGF-like-domain, multiple 6provided by RGD
    Primary source
    RGD:1563321
    See related
    EnsemblRapid:ENSRNOG00000004275 AllianceGenome:RGD:1563321
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in basement membrane. Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 341.4) and Kidney (RPKM 39.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Egfl6 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (31515752..31573699)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (27884087..27942044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (29430789..29488737)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551617 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene stabilizer of axonemal microtubules like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor-like protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108254.1 → NP_001101724.1  epidermal growth factor-like protein 6 precursor

      See identical proteins and their annotated locations for NP_001101724.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474014
      UniProtKB/TrEMBL
      A0A0G2KB47, A6K2H3, D3Z8B8
      Related
      ENSRNOP00000062411.3, ENSRNOT00000068337.5
      Conserved Domains (3) summary
      cd06263
      Location:394 → 507
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00179
      Location:172 → 205
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:221 → 256
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      31515752..31573699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099835.2 → XP_038955763.1  epidermal growth factor-like protein 6 isoform X1

      Conserved Domains (4) summary
      smart00179
      Location:92 → 123
      EGF_CA; Calcium-binding EGF-like domain
      pfam07645
      Location:172 → 207
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:221 → 256
      EGF_3; EGF domain
      cl27660
      Location:400 → 419
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

    2. XM_039099836.2 → XP_038955764.1  epidermal growth factor-like protein 6 isoform X2

      Conserved Domains (4) summary
      smart00179
      Location:92 → 123
      EGF_CA; Calcium-binding EGF-like domain
      pfam07645
      Location:172 → 207
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:221 → 256
      EGF_3; EGF domain
      cl27660
      Location:399 → 418
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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