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    Rimbp2 RIMS binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266780, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rimbp2provided by RGD
    Official Full Name
    RIMS binding protein 2provided by RGD
    Primary source
    RGD:708533
    See related
    EnsemblRapid:ENSRNOG00000022893 AllianceGenome:RGD:708533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbp2; RIM-BP2
    Summary
    Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 95.4), Brain (RPKM 54.2) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Rimbp2 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33383646..33582259)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27747615..27946256)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31393229..31605567)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene syntaxin 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene uncharacterized LOC108352441 Neighboring gene piwi-like RNA-mediated gene silencing 1 Neighboring gene frizzled class receptor 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in calyx of Held  
    is_active_in glutamatergic synapse  
    located_in plasma membrane  
    is_active_in presynaptic active zone cytoplasmic component  

    General protein information

    Preferred Names
    RIMS-binding protein 2
    Names
    RIM binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100488.4NP_001093958.1  RIMS-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZR68, A0A8I6A6H1
      Related
      ENSRNOP00000080836.1, ENSRNOT00000100361.2
      Conserved Domains (6) summary
      cd12012
      Location:876937
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:9801040
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:414478
      fn3; Fibronectin type III domain
      pfam15152
      Location:642683
      Kisspeptin; Kisspeptin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      33383646..33582259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271095.1XP_063127165.1  RIMS-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000073070.3, ENSRNOT00000086078.3
    2. XM_063271096.1XP_063127166.1  RIMS-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4J8
    3. XM_039089127.2XP_038945055.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000059643.3, ENSRNOT00000067867.6
      Conserved Domains (7) summary
      cd12012
      Location:11061167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12101270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15905
      Location:488
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    4. XM_063271099.1XP_063127169.1  RIMS-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6H1, A6J0T2
    5. XM_063271100.1XP_063127170.1  RIMS-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A6H1
    6. XM_063271097.1XP_063127167.1  RIMS-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6H1
    7. XM_039089126.2XP_038945054.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Conserved Domains (7) summary
      cd12012
      Location:11061167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12101270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15905
      Location:488
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    8. XM_063271102.1XP_063127172.1  RIMS-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A6H1
      Related
      ENSRNOP00000087009.1, ENSRNOT00000115151.2
    9. XM_039089128.2XP_038945056.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000030915.5, ENSRNOT00000033379.6
      Conserved Domains (7) summary
      cd12012
      Location:11061167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12101270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15905
      Location:488
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    10. XM_039089129.2XP_038945057.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Conserved Domains (7) summary
      cd12012
      Location:11061167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12101270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15905
      Location:488
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    11. XM_063271098.1XP_063127168.1  RIMS-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6H1
      Related
      ENSRNOP00000111280.1, ENSRNOT00000158624.1
    12. XM_063271094.1XP_063127164.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
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