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    Gpr149 G protein-coupled receptor 149 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr149provided by RGD
    Official Full Name
    G protein-coupled receptor 149provided by RGD
    Primary source
    RGD:619890
    See related
    EnsemblRapid:ENSRNOG00000014793 AllianceGenome:RGD:619890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ieda
    Summary
    Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be active in neuron projection and plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.2), Testes (RPKM 3.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr149 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (149059333..149130798, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (146909710..146981924, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (152838836..152912027, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC134485922 Neighboring gene uncharacterized LOC120100834 Neighboring gene DEAH-box helicase 36 Neighboring gene RNA, U6 small nuclear 1286 Neighboring gene uncharacterized LOC134485788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. De Smet C, et al. J Neurochem, 2002 May. PMID 12065666
    2. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Edson MA, et al. Endocrinology, 2010 Jan. PMID 19887567, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ovulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within preantral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 149
    Names
    induced early in differentiating astrocytes gene protein
    orphan seven transmembrane receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433874.1 → NP_001420803.1  probable G-protein coupled receptor 149 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NM_001433876.1 → NP_001420805.1  probable G-protein coupled receptor 149 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    3. NM_138891.2 → NP_620246.1  probable G-protein coupled receptor 149 isoform 1

      See identical proteins and their annotated locations for NP_620246.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q924Y8
      UniProtKB/TrEMBL
      A6JVN3
      Related
      ENSRNOP00000019929.2, ENSRNOT00000019929.5
      Conserved Domains (1) summary
      pfam00001
      Location:54 → 209
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_197598.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      149059333..149130798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101674.2 → XP_038957602.1  probable G-protein coupled receptor 149 isoform X1

      Conserved Domains (1) summary
      cd15011
      Location:35 → 372
      7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924Y8.1 GenPept UniProtKB/Swiss-Prot:Q924Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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